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Diet High In Omega-3 Fatty Acids May Help Prevent A Leading Cause Of Blindness Among Elderly

Date:
July 25, 2009
Source:
American Journal of Pathology
Summary:
Current research suggests that a diet high in omega-3 fatty acids may help prevent one of the leading causes of legal blindness among the elderly. Age-related macular degeneration (AMD), loss of vision in the center of the visual field (macula) due to retinal damage, is one of the leading causes of legal blindness among the elderly. Approximately 10% of people from 66 to 74 years of age will develop some level of macular degeneration, making it difficult for them to read or even recognize faces.

Current research suggests that a diet high in omega-3 fatty acids may help prevent one of the leading causes of legal blindness among the elderly. The related report by Tuo et al, "A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration," appears in the August 2009 issue of the American Journal of Pathology.

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Age-related macular degeneration (AMD), loss of vision in the center of the visual field (macula) due to retinal damage, is one of the leading causes of legal blindness among the elderly. Approximately 10% of people from 66 to 74 years of age will develop some level of macular degeneration, making it difficult for them to read or even recognize faces.

A diet high in omega-3 fatty acids has been found to protect against a variety of diseases including atherosclerosis and Alzheimer's disease. Retrospective studies have suggested that diets high in fish oil or omega-3 fatty acids may also contribute to protection against AMD. A group led by Dr. Chi-Chao Chan at the National Eye Institute in Bethesda, MD examined the direct effect of omega-3 fatty acids on a mouse model of AMD. A diet with high levels of omega-3 fatty acids resulted in slower lesion progression, with improvement in some lesions. These mice had lower levels of inflammatory molecules and higher levels of anti-inflammatory molecules, which may explain this protective effect.

Tuo et al suggest that "a diet enriched in EPA and DHA can ameliorate the progression of retinal lesions in their mouse model of AMD" and that "the results in these mice are in line with the epidemiological studies of AMD risk reduction by long chain n-3 fatty acids." The results "further provide the scientific basis for the application of omega-3 fatty acids and their biologically active derivatives in the prevention and treatment of AMD." In future studies, Dr. Chan and colleagues plan to use this murine model "to evaluate [other] therapies that might delay the development of AMD." Their ongoing projects include the "testing of systematic delivered pharmacochaperones and antioxidative molecules, as well as intraocularly delivered gene therapies."

This work was supported by grants from The Intramural Research Program of the National Eye Institute, the National Institutes of Health, and the American Health Assistance Foundation.


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tuo et al. A High Omega-3 Fatty Acid Diet Reduces Retinal Lesions in a Murine Model of Macular Degeneration. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.090089

Cite This Page:

American Journal of Pathology. "Diet High In Omega-3 Fatty Acids May Help Prevent A Leading Cause Of Blindness Among Elderly." ScienceDaily. ScienceDaily, 25 July 2009. <www.sciencedaily.com/releases/2009/07/090723081518.htm>.
American Journal of Pathology. (2009, July 25). Diet High In Omega-3 Fatty Acids May Help Prevent A Leading Cause Of Blindness Among Elderly. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/07/090723081518.htm
American Journal of Pathology. "Diet High In Omega-3 Fatty Acids May Help Prevent A Leading Cause Of Blindness Among Elderly." ScienceDaily. www.sciencedaily.com/releases/2009/07/090723081518.htm (accessed March 29, 2015).

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