Featured Research

from universities, journals, and other organizations

Virulence Of Pandemic H1N1 Virus In Swine Populations

Date:
August 3, 2009
Source:
Kansas State University
Summary:
Laboratory studies are making headway in the effort to control the pandemic H1N1 virus. Researchers are developing better testing tools, creating a "diagnostic arsenal" to use if H1N1 were to spread to swine populations.

Laboratory studies at Kansas State University and the work of a K-State researcher are making headway in the effort to control the pandemic H1N1 virus.

Juergen Richt is a Regents Distinguished Professor at K-State's College of Veterinary Medicine and is a Kansas Bioscience Authority Eminent Scholar. His work at K-State and with outside collaborators is revealing the characteristics of the pandemic H1N1 virus.

Richt is among the K-State researchers who study zoonotic disease -- those that can be transmitted from animals to humans and vice versa. Zoonotic diseases will be a focus of the National Agro and Bio-Defense Facility that has been designated for Manhattan.

"Our strength at K-State is that we are very familiar with zoonotic diseases and we can contribute by working on models for animal and human diseases," Richt said. "This expertise is very critical now that an agent causing a pandemic flu in humans most likely originated in animal populations."

At K-State, Richt is leading in vitro research to develop better testing tools, creating a "diagnostic arsenal" if H1N1 were to spread to swine populations. Richt said they are developing diagnostic tools for the direct detection of the virus by finding nucleic acids or other parts of the virus in a sample, as well as tools for indirect detection. The latter approach is done by creating diagnostics that detect antibodies produced by animals infected with the virus.

"We do this work to protect the pig industry in case the virus would jump into the swine population," Richt said.

His work with outside collaborators is testing the virulence of pandemic H1N1 in animal models. In pigs, Richt and his fellow researchers found that pandemic H1N1 does infect pigs and transmits between the animals but is not fatal.

"Its important to know the clinical and pathological effects this virus has on pigs," Richt said. "It is also important to perform these experiments because we produce reagents in the pigs that we use later for diagnostic purposes as controls to validate our testing systems."

The researchers also studied the virulence of two strains of the pandemic H1N1 virus in a nonhuman primate model as a way to predict how the strains would affect humans. Comparing an isolate from California with one from Mexico, Richt and his collaborators found that the California isolate was more virulent than the Mexico isolate. Both pandemic H1N1 viruses are more virulent than seasonal H1N1 flu viruses.

"With different isolates, there are different clinical outcomes," he said.

Establishing animal models for pandemic H1N1 is important, Richt said, because physicians have two types of antiviral medications to treat influenza. One type, called adamantine-like drugs, targets the M2 protein; the other type includes drugs like Tamiflu that target the neuraminidase protein. He said that this pandemic H1N1 is already resistant to the M2 inhibitors but still is sensitive to Tamiflu.

"Some pandemic flu isolates from humans have now shown resistance to the Tamiflu," Richt said. "So the big issue now is if these Tamiflu-resistant strains take over, we have no drug to treat infected patients. And because we don't have a vaccine yet in the United States, this might be a problem.

"Pandemic H1N1 is another example of how important it is to work on the nexus of human and animal health," he said.


Story Source:

The above story is based on materials provided by Kansas State University. Note: Materials may be edited for content and length.


Cite This Page:

Kansas State University. "Virulence Of Pandemic H1N1 Virus In Swine Populations." ScienceDaily. ScienceDaily, 3 August 2009. <www.sciencedaily.com/releases/2009/07/090730111200.htm>.
Kansas State University. (2009, August 3). Virulence Of Pandemic H1N1 Virus In Swine Populations. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/07/090730111200.htm
Kansas State University. "Virulence Of Pandemic H1N1 Virus In Swine Populations." ScienceDaily. www.sciencedaily.com/releases/2009/07/090730111200.htm (accessed July 25, 2014).

Share This




More Plants & Animals News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Dogs Appear To Become Jealous Of Owners' Attention

Dogs Appear To Become Jealous Of Owners' Attention

Newsy (July 23, 2014) A U.C. San Diego researcher says jealousy isn't just a human trait, and dogs aren't the best at sharing the attention of humans with other dogs. Video provided by Newsy
Powered by NewsLook.com
Professor Creates Site Revealing Where People's Cats Live

Professor Creates Site Revealing Where People's Cats Live

Newsy (July 23, 2014) ​It's called I Know Where Your Cat Lives, and you can keep hitting the "Random Cat" button to find more real cats all over the world. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins