Featured Research

from universities, journals, and other organizations

A High Fat Diet During Pregnancy Can Lead To Severe Liver Disease In Offspring

Date:
October 13, 2009
Source:
University of Southampton
Summary:
Scientists have discovered a previously unknown link between a mother's diet in pregnancy and non-alcoholic fatty liver disease in her child. Researchers have found that a high fat diet during a woman's pregnancy makes her offspring more likely to develop a severe form of fatty liver disease when they reach adulthood. The findings are another piece in the jigsaw for scientists who believe diets containing too high levels of saturated fat may have an adverse effect on our health.

Scientists have discovered a previously unknown link between a mother’s diet in pregnancy and a severe form of liver disease in her child.

Related Articles


In a study, published in the journal Hepatology, researchers at the University of Southampton found that a high fat diet during a woman’s pregnancy makes her offspring more likely to develop a severe form of fatty liver disease when they reach adulthood. The findings are another piece in the jigsaw for scientists who believe diets containing too high levels of saturated fat may have an adverse effect on our health.

Non-alcoholic fatty liver disease (NAFLD) is a condition associated with obesity and caused by the build up of fat in the liver. The condition advances in some people and it is important to understand the factors that contribute to disease progression. Until recently, NAFLD was considered rare and relatively harmless but now it is one of the most common forms of liver disease that may progress to cirrhosis a serious life threatening chronic liver disease.

Professor Christopher Byrne, with colleagues Dr Felino Cagampang and Dr Kim Bruce, of the University’s School of Medicine and researchers at King’s College London, conducted the study, funded by the BBSRC. Prof Byrne explained: “This research shows that too much saturated fat in a mother’s diet can affect the developing liver of a fetus, making it more susceptible to developing fatty liver disease later in life. An unhealthy saturated fat-enriched diet in the child and young adult compounds the problem further causing a severe form of the fatty liver disease later in adult life."

The next stage of this research, also funded by the BBSRC, will be to understand, more precisely, the reason why fatty liver disease develops and to intervene to prevent the fatty liver disease occurring.

The University’s School of Medicine has a worldwide reputation for its pioneering research into the relationship between mothers’ diets in pregnancy and future health problems in their offspring.


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bruce et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology, 2009 DOI: 10.1002/hep.23205

Cite This Page:

University of Southampton. "A High Fat Diet During Pregnancy Can Lead To Severe Liver Disease In Offspring." ScienceDaily. ScienceDaily, 13 October 2009. <www.sciencedaily.com/releases/2009/10/091012095705.htm>.
University of Southampton. (2009, October 13). A High Fat Diet During Pregnancy Can Lead To Severe Liver Disease In Offspring. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2009/10/091012095705.htm
University of Southampton. "A High Fat Diet During Pregnancy Can Lead To Severe Liver Disease In Offspring." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012095705.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins