Featured Research

from universities, journals, and other organizations

Mechanism For Neuron Self-preservation Discovered

Date:
October 24, 2009
Source:
Rockefeller University Press
Summary:
Scientists found that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement.

With glutamate stimulation (right), CaV1.2 channels (red) are internalized and degraded by cortical neurons under PIKfyve's direction.
Credit: Tsuruta, F., et al. 2009. J. Cell Biol. doi:10.1083/jcb.200903028.

Tsuruta et al. find that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement. The study appears in the October 19, 2009 issue of the Journal of Cell Biology.

An important player in cellular signaling, calcium is also terribly toxic at high levels. Neurons have evolved ways to protect themselves against the calcium influxes that come during periods of intense electrical activity. One way to limit the calcium flood is to remove the gatekeepers, calcium channels, from the cell surface. How neurons direct this is clinically important in a range of disorders, including stroke, Parkinson's disease, and Alzheimer's disease.

In a proteomic screen for binding partners of the CaV1.2 channel, Tsuruta et al. extracted what seemed a strange companion at first: PIKfyve, the lipid kinase that generates PI(3,5)P2 and promotes the maturation of endosomes into lysosomes. Other groups had recently shown that mutations affecting PI(3,5)P2 production cause degeneration of excitable cells in both mice and humans, including mutants found in ALS and Charcot-Marie-Tooth disease. The team hypothesized that PIKfyve might be directing CaV1.2 degradation. Using glutamate excitation to simulate excitotoxic stress, the authors showed that CaV1.2 is internalized, associates with PIKfyve, and is degraded in the lysosome. When Tsuruta et al. squelched levels of PIKfyve or PI(3,5)P2, excess channels stayed at the surface and left neurons vulnerable to apoptosis.

The findings clarify how this neuroprotective mechanism unfolds and suggest that existing calcium channel-blocking drugs might aid patients with neurodegenerative disorders stemming from a PI(3,5)P2 defect.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tsuruta et al. PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. The Journal of Cell Biology, 2009; 187 (2): 279 DOI: 10.1083/jcb.200903028

Cite This Page:

Rockefeller University Press. "Mechanism For Neuron Self-preservation Discovered." ScienceDaily. ScienceDaily, 24 October 2009. <www.sciencedaily.com/releases/2009/10/091019122846.htm>.
Rockefeller University Press. (2009, October 24). Mechanism For Neuron Self-preservation Discovered. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2009/10/091019122846.htm
Rockefeller University Press. "Mechanism For Neuron Self-preservation Discovered." ScienceDaily. www.sciencedaily.com/releases/2009/10/091019122846.htm (accessed September 1, 2014).

Share This




More Plants & Animals News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins