Featured Research

from universities, journals, and other organizations

Previously unknown gene is unique to placental mammals

Date:
December 18, 2009
Source:
Uppsala University
Summary:
Researchers have discovered a previously unknown gene ZBED6 that is unique to placental mammals. The gene originates from a so called jumping gene that integrated in the genome of a primitive mammal at least 150 million years ago and has since then evolved an essential function.

Researchers at Uppsala University, Swedish University of Agricultural Sciences and Broad Institute have discovered a previously unknown gene ZBED6 that is unique to placental mammals. The gene originates from a so called jumping gene that integrated in the genome of a primitive mammal at least 150 million years ago and has since then evolved an essential function. The study is published in PLoS Biology.

Related Articles


Domestic pigs develop more muscle and store less fat than their wild ancestor, the wild boar.

"This is a result of the systematic selection that has been ongoing the last 60 years to breed pigs that produce the lean meat the consumers prefer," says Leif Andersson who led the study. "This explains why a pork chop today contains much less fat compared with the pork chops produced a hundred years ago."

Leif Andersson and his colleagues decided already twenty years ago to cross the wild boar with the domestic pig in an attempt to find genetic explanations for this selection response in pigs. Some years ago they discovered a specific mutation in a non-coding DNA sequence that regulates the expression of an important growth factor, IGF2. This mutation contributes very significantly to the difference in muscle growth between pigs and wild boars.

"We have now in collaboration with researchers at the Broad Institute used a sophisticated molecular method to isolate the protein that binds the DNA sequence that is altered in pigs," says Lin Jiang, one of the PhD students associated with the project. "Surprisingly, the protein is previously unknown and we named it ZBED6. The protein is present in all placental mammals including humans."

Barbara McClintock received the Nobel prize 1983 for her important discovery of "jumping genes" in the genome. It is now reported that ZBED6 has evolved from a member of the same family of jumping genes as McClintock studied in maize. The ZBED6 ancestor integrated in the genome of a primitive mammal at least 150 million years before present. It has since then been domesticated and is now stably integrated in the genome at the same position in all placental mammals.

"Our finding that the DNA-binding parts of the protein are 100% identical among all mammals that we have investigated including humans shows that ZBED6 must have evolved an essential function," says Lin Jiang.

The new results show that ZBED6 does not only regulate the expression of the IGF2 growth factor in pig muscle but appears to regulate hundreds if not thousands of other genes in mammals.

"The results indicate that we have discovered a new "orchestra conductor" that controls the activities of many genes in the mammalian cell," says Leif Andersson. "It will be very exciting to further study the biological significance of ZBED6 and find out to which extent the action of this factor influences various diseases in humans."

The study is a beautiful illustration that strong basic research leads to unexpected discoveries, Leif Andersson concludes. They started this project 20 years ago by asking the question: What are the genetic mechanisms explaining the remarkable increase in muscle growth in the domestic pig. This led to the discovery of the IGF2 mutation and a previously unknown mechanism that regulates muscle mass.

"Now we have discovered a previously unknown protein that originates from a jumping gene and this protein appears to have an important regulatory role during development. The discovery provides new basic knowledge concerning the evolution of placental mammals and is of considerable biomedical significance," says Leif Andersson.


Story Source:

The above story is based on materials provided by Uppsala University. Note: Materials may be edited for content and length.


Cite This Page:

Uppsala University. "Previously unknown gene is unique to placental mammals." ScienceDaily. ScienceDaily, 18 December 2009. <www.sciencedaily.com/releases/2009/12/091214201012.htm>.
Uppsala University. (2009, December 18). Previously unknown gene is unique to placental mammals. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2009/12/091214201012.htm
Uppsala University. "Previously unknown gene is unique to placental mammals." ScienceDaily. www.sciencedaily.com/releases/2009/12/091214201012.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Baby Okapi Born at Houston Zoo

Raw: Baby Okapi Born at Houston Zoo

AP (Nov. 20, 2014) The Houston Zoo released video of a male baby okapi. Okapis, also known as the "forest giraffe", are native to the Democratic Republic of the Congo in Central Africa. Video is mute from source. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins