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It's good to talk: Changing how nerves communicate in congestive heart failure

Date:
January 7, 2010
Source:
Journal of Clinical Investigation
Summary:
A team of researchers has now determined in rodents how congestive heart failure triggers substantive changes to the nerves that control heart function.

A team of researchers, led by Keiichi Fukuda, at Keio University School of Medicine, Tokyo, Japan, has now determined in rodents how congestive heart failure triggers substantive changes to the nerves that control heart function.

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The research appears in the Journal of Clinical Investigation.

Heart function is controlled by both the sympathetic nervous system and the parasympathetic nervous system. In congestive heart failure, increased activation of the sympathetic nervous system causes damage to the heart muscle, a decline in heart function, and potentially lethal abnormal heartbeats.

In the study, failing rat heart muscle cells were found to secrete molecules known as gp130-signaling cytokines that caused sympathetic nerves to change the molecule that they used to communicate from norepinephrine to acetylcholine.

The clinical significance of these observations in rodents was highlighted by the fact that the sympathetic nervous system in the heart of patients with congestive heart failure showed evidence of the same switch to reliance on acetylcholine for communication.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hideaki Kanazawa, Masaki Ieda, Kensuke Kimura, Takahide Arai, Haruko Kawaguchi-Manabe, Tomohiro Matsuhashi, Jin Endo, Motoaki Sano, Takashi Kawakami, Tokuhiro Kimura, Toshiaki Monkawa, Matsuhiko Hayashi, Akio Iwanami, Hideyuki Okano, Yasunori Okada, Hatsue Ishibashi-Ueda, Satoshi Ogawa and Keiichi Fukuda. Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39778

Cite This Page:

Journal of Clinical Investigation. "It's good to talk: Changing how nerves communicate in congestive heart failure." ScienceDaily. ScienceDaily, 7 January 2010. <www.sciencedaily.com/releases/2010/01/100104210709.htm>.
Journal of Clinical Investigation. (2010, January 7). It's good to talk: Changing how nerves communicate in congestive heart failure. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/01/100104210709.htm
Journal of Clinical Investigation. "It's good to talk: Changing how nerves communicate in congestive heart failure." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104210709.htm (accessed November 26, 2014).

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