Featured Research

from universities, journals, and other organizations

New finding in cell migration may be key to preventing clots, cancer spread

Date:
January 15, 2010
Source:
University of Illinois at Chicago
Summary:
Researchers have discovered how cells in the body flatten out as they adhere to internal bodily surfaces, the first step in a wide range of important processes including clot formation, immune defense, wound healing, and the spread of cancer cells.

Researchers at the University of Illinois at Chicago College of Medicine have discovered how cells in the body flatten out as they adhere to internal bodily surfaces, the first step in a wide range of important processes including clot formation, immune defense, wound healing, and the spread of cancer cells.

Related Articles


Their study is published in the January 15 issue of Science.

Xiaoping Du, UIC professor of pharmacology, and his colleagues were trying to better understand how platelets in the blood form clots. Clots that form in blood vessels can lead to heart attack and stroke.

To form clots, platelets flatten out to seal the wound and to bind to each other, a process called "spreading." Spreading is the first step in a number of cell processes, Du says.

In order for cells to move, they must adhere and spread onto the extracellular matrix, a scaffolding of fibers that supports cells. Only then is the cell able to crawl along -- whether it be an immune cell moving toward a wound, or a cancer cell invading neighboring tissue.

Adhesion to the extracellular matrix is mediated by cell receptors called integrins. Du's team "found the mechanism for the transmission of the signal to spread" by the integrins, he said.

The integrin molecule spans the cell membrane, with a portion of the integrin inside the cell and another part outside.

When the outside part of the integrin molecule binds to the matrix, a signal is sent inside the cell via a G protein, a type of protein involved in cell signaling but that was not previously known to interact with integrins.

Du and his colleagues found that the G protein G-alpha-13 binds to the inner side of the integrin molecule when the outside portion binds to the matrix. G-alpha-13 then inhibits a molecule called RhoA, which normally allows the cell to maintain a spherical shape. When RhoA is inhibited by G-alpha-13, the cell is able to flatten out and spread onto the matrix.

Because the factors involved in this first step in spreading are common to virtually all cells, Du believes that the mechanism is likely universal.

"Understanding these fundamental processes has the potential to allow us to develop drugs to treat thrombosis, stroke and heart attack," he said, and may lead to drugs that could stop cancer cells from migrating.

The study was supported by grants from the National Heart Lung and Blood Institute, one of the National Institutes of Health. Haixia Gong, Bo Shen, Panagiotis Flevaris, Christina Chow, Stephen Lam, Tatyana Voyno-Yasenetskaya, and Tohru Kozasa, all of the department of pharmacology in the UIC College of Medicine, contributed to the study.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "New finding in cell migration may be key to preventing clots, cancer spread." ScienceDaily. ScienceDaily, 15 January 2010. <www.sciencedaily.com/releases/2010/01/100114143319.htm>.
University of Illinois at Chicago. (2010, January 15). New finding in cell migration may be key to preventing clots, cancer spread. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/01/100114143319.htm
University of Illinois at Chicago. "New finding in cell migration may be key to preventing clots, cancer spread." ScienceDaily. www.sciencedaily.com/releases/2010/01/100114143319.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins