Featured Research

from universities, journals, and other organizations

A role for the protein c-Myb in leukemia

Date:
January 19, 2010
Source:
Journal of Clinical Investigation
Summary:
Our genes are arranged on 23 pairs of chromosomes. Chromosomal abnormalities that occur when nonmatching pairs of chromosomes swap genetic information are known as chromosomal translocations. Chromosomal translocations are the cause of several forms of leukemia, as they can result in dysregulation of genes that cause cancer. The gene MLL is often inappropriately regulated in acute leukemias caused by chromosomal translocation, and researchers have now identified a molecular pathway that is important for inducing MLL-associated leukemia formation.

Our genes are arranged on 23 pairs of chromosomes. Chromosomal abnormalities that occur when nonmatching pairs of chromosomes swap genetic information are known as chromosomal translocations. Chromosomal translocations are the cause of several forms of leukemia, as they can result in dysregulation of genes that cause cancer.

The gene MLL is often inappropriately regulated in acute leukemias caused by chromosomal translocation, and Alan Gewirtz and colleagues, at the University of Pennsylvania School of Medicine, Philadelphia, have now identified a molecular pathway that is important for inducing MLL-associated leukemia formation.

In the study, the authors find that in human leukemia cells the protein c-myb binds to MLL via the protein menin and that this is important for MLL to drive mouse blood cells to become leukemic. Further analysis indicated that the c-myb/menin/MLL complex induced changes to genomic structure, leading to changes in gene expression. The authors suggest that deeper understanding of the gene networks regulated by the c-myb/menin/MLL complex might provide new drug targets for treatments for acute leukemia.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shenghao Jin, Huiwu Zhao, Yan Yi, Yuji Nakata, Anna Kalota and Alan M. Gewirtz. c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI38030

Cite This Page:

Journal of Clinical Investigation. "A role for the protein c-Myb in leukemia." ScienceDaily. ScienceDaily, 19 January 2010. <www.sciencedaily.com/releases/2010/01/100119224847.htm>.
Journal of Clinical Investigation. (2010, January 19). A role for the protein c-Myb in leukemia. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2010/01/100119224847.htm
Journal of Clinical Investigation. "A role for the protein c-Myb in leukemia." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119224847.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins