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A role for the protein c-Myb in leukemia

Date:
January 19, 2010
Source:
Journal of Clinical Investigation
Summary:
Our genes are arranged on 23 pairs of chromosomes. Chromosomal abnormalities that occur when nonmatching pairs of chromosomes swap genetic information are known as chromosomal translocations. Chromosomal translocations are the cause of several forms of leukemia, as they can result in dysregulation of genes that cause cancer. The gene MLL is often inappropriately regulated in acute leukemias caused by chromosomal translocation, and researchers have now identified a molecular pathway that is important for inducing MLL-associated leukemia formation.

Our genes are arranged on 23 pairs of chromosomes. Chromosomal abnormalities that occur when nonmatching pairs of chromosomes swap genetic information are known as chromosomal translocations. Chromosomal translocations are the cause of several forms of leukemia, as they can result in dysregulation of genes that cause cancer.

The gene MLL is often inappropriately regulated in acute leukemias caused by chromosomal translocation, and Alan Gewirtz and colleagues, at the University of Pennsylvania School of Medicine, Philadelphia, have now identified a molecular pathway that is important for inducing MLL-associated leukemia formation.

In the study, the authors find that in human leukemia cells the protein c-myb binds to MLL via the protein menin and that this is important for MLL to drive mouse blood cells to become leukemic. Further analysis indicated that the c-myb/menin/MLL complex induced changes to genomic structure, leading to changes in gene expression. The authors suggest that deeper understanding of the gene networks regulated by the c-myb/menin/MLL complex might provide new drug targets for treatments for acute leukemia.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shenghao Jin, Huiwu Zhao, Yan Yi, Yuji Nakata, Anna Kalota and Alan M. Gewirtz. c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI38030

Cite This Page:

Journal of Clinical Investigation. "A role for the protein c-Myb in leukemia." ScienceDaily. ScienceDaily, 19 January 2010. <www.sciencedaily.com/releases/2010/01/100119224847.htm>.
Journal of Clinical Investigation. (2010, January 19). A role for the protein c-Myb in leukemia. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2010/01/100119224847.htm
Journal of Clinical Investigation. "A role for the protein c-Myb in leukemia." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119224847.htm (accessed October 20, 2014).

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