Prof. Claudio Cuello at McGill University and his collaborators have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments.
Alzheimer's is a devastating brain condition leading to a progressive decline of memory and other brain functions. Although research mice have been developed in the past, rats are more intelligent than other rodents and the behavior of these rats is rich and predictable, which means that for the first time researchers will be able to detect and study the evolution of learning and memory deficits.
Moreover, researchers can now study a suspected "latent phase" of Alzheimer's disease. The disease is caused by the accumulation in the brain of molecules known as peptides. This accumulation has been repeated in lab mice, but the human condition develops through different stages and these rats enable this progression to be mimicked for the first time.
Studies of this phase were previously impossible as humans do not have biochemical markers that would allow the development of Alzheimer's to be predicted.
The research was published in the Journal of Alzheimer's Disease.
Prof. Cuello's work has been done with the financial support of the Canadian Institutes of Health Research and the Charles E Frosst/Merck Postdoctoral Fellowship Fund and with the collaboration with Leena Alhonen at Kuopio University in Finland and Fabio Canneva, Adriana Ducatenzeiler, Wanda Leon and Moshe Szyf of McGill's Department of Pharmacology and Therapeutics.
- Wanda Carolina Leon, Fabio Canneva, Vanessa Partridge, Simon Allard, Maria Teresa Ferretti, Arald Dewilde, Freya Vercauteren, Ramtin Atifeh, Adriana Ducatenzeiler, William Klein, Moshe Szyf, Leena Alhonen, A. Claudio Cuello. A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment. Journal of Alzheimer's Disease, 2010; (in press) [link]
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