Featured Research

from universities, journals, and other organizations

Alzheimer's rat created for human research

Date:
March 30, 2010
Source:
McGill University
Summary:
Researchers have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments.

Prof. Claudio Cuello at McGill University and his collaborators have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments.

Related Articles


Alzheimer's is a devastating brain condition leading to a progressive decline of memory and other brain functions. Although research mice have been developed in the past, rats are more intelligent than other rodents and the behavior of these rats is rich and predictable, which means that for the first time researchers will be able to detect and study the evolution of learning and memory deficits.

Moreover, researchers can now study a suspected "latent phase" of Alzheimer's disease. The disease is caused by the accumulation in the brain of molecules known as peptides. This accumulation has been repeated in lab mice, but the human condition develops through different stages and these rats enable this progression to be mimicked for the first time.

Studies of this phase were previously impossible as humans do not have biochemical markers that would allow the development of Alzheimer's to be predicted.

The research was published in the Journal of Alzheimer's Disease.

Prof. Cuello's work has been done with the financial support of the Canadian Institutes of Health Research and the Charles E Frosst/Merck Postdoctoral Fellowship Fund and with the collaboration with Leena Alhonen at Kuopio University in Finland and Fabio Canneva, Adriana Ducatenzeiler, Wanda Leon and Moshe Szyf of McGill's Department of Pharmacology and Therapeutics.


Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wanda Carolina Leon, Fabio Canneva, Vanessa Partridge, Simon Allard, Maria Teresa Ferretti, Arald Dewilde, Freya Vercauteren, Ramtin Atifeh, Adriana Ducatenzeiler, William Klein, Moshe Szyf, Leena Alhonen, A. Claudio Cuello. A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment. Journal of Alzheimer's Disease, 2010; (in press) [link]

Cite This Page:

McGill University. "Alzheimer's rat created for human research." ScienceDaily. ScienceDaily, 30 March 2010. <www.sciencedaily.com/releases/2010/03/100329133602.htm>.
McGill University. (2010, March 30). Alzheimer's rat created for human research. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/03/100329133602.htm
McGill University. "Alzheimer's rat created for human research." ScienceDaily. www.sciencedaily.com/releases/2010/03/100329133602.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins