Featured Research

from universities, journals, and other organizations

Alzheimer's rat created for human research

Date:
March 30, 2010
Source:
McGill University
Summary:
Researchers have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments.

Prof. Claudio Cuello at McGill University and his collaborators have genetically manipulated rats that can emulate Alzheimer's disease in humans, enabling research that will include the development of new treatments.

Alzheimer's is a devastating brain condition leading to a progressive decline of memory and other brain functions. Although research mice have been developed in the past, rats are more intelligent than other rodents and the behavior of these rats is rich and predictable, which means that for the first time researchers will be able to detect and study the evolution of learning and memory deficits.

Moreover, researchers can now study a suspected "latent phase" of Alzheimer's disease. The disease is caused by the accumulation in the brain of molecules known as peptides. This accumulation has been repeated in lab mice, but the human condition develops through different stages and these rats enable this progression to be mimicked for the first time.

Studies of this phase were previously impossible as humans do not have biochemical markers that would allow the development of Alzheimer's to be predicted.

The research was published in the Journal of Alzheimer's Disease.

Prof. Cuello's work has been done with the financial support of the Canadian Institutes of Health Research and the Charles E Frosst/Merck Postdoctoral Fellowship Fund and with the collaboration with Leena Alhonen at Kuopio University in Finland and Fabio Canneva, Adriana Ducatenzeiler, Wanda Leon and Moshe Szyf of McGill's Department of Pharmacology and Therapeutics.


Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wanda Carolina Leon, Fabio Canneva, Vanessa Partridge, Simon Allard, Maria Teresa Ferretti, Arald Dewilde, Freya Vercauteren, Ramtin Atifeh, Adriana Ducatenzeiler, William Klein, Moshe Szyf, Leena Alhonen, A. Claudio Cuello. A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment. Journal of Alzheimer's Disease, 2010; (in press) [link]

Cite This Page:

McGill University. "Alzheimer's rat created for human research." ScienceDaily. ScienceDaily, 30 March 2010. <www.sciencedaily.com/releases/2010/03/100329133602.htm>.
McGill University. (2010, March 30). Alzheimer's rat created for human research. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2010/03/100329133602.htm
McGill University. "Alzheimer's rat created for human research." ScienceDaily. www.sciencedaily.com/releases/2010/03/100329133602.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins