Featured Research

from universities, journals, and other organizations

Sheep virus life cycle that causes malignant catarrhal fever explained

Date:
April 5, 2010
Source:
USDA/Agricultural Research Service
Summary:
The mysterious life cycle of a sheep virus that causes malignant catarrhal fever has been discovered by agricultural scientists -- the first step in developing a vaccine against the disease.

Scientists have uncovered the mysterious life cycle of a virus that passes from sheep to bison and cattle, causing malignant catarrhal fever.
Credit: Photo by Peggy Greb

The mysterious life cycle of a sheep virus that causes malignant catarrhal fever (MCF) has been discovered by Agricultural Research Service (ARS) scientists and their university collaborators -- the first step in developing a vaccine against the disease.

Microbiologist Hong Li and veterinary medical officer Naomi Taus at the ARS Animal Diseases Research Unit in Pullman, Wash., collaborated on the research with Lindsay Oaks at Washington State University and Donal O'Toole at the University of Wyoming.

MCF, a viral infection that is a leading cause of disease in American bison, is usually transmitted from sheep to bison and cattle. Vaccine development has been stymied because the virus won't grow in cell culture.

The ARS scientists and their university colleagues have shown that the virus undergoes several changes inside the animal's body, targeting specific cell types at different stages of its own life cycle. This process is called "cell tropism switching."

The viral replication in sheep can be divided into three stages: entry, maintenance, and shedding. The virus enters the sheep through its nasal passages and reaches the lungs, where it replicates. Replication in the sheep lung is required for the virus to change its cell tropism for the next stage: the infection of lymphocytes, a type of immune cell.

During this maintenance stage, the virus stays in the lymphocytes that circulate through the whole body, with little replication. This type of infection is referred to as a "latent infection." During the shedding stage, the virus reactivates from the infected lymphocytes and targets specific cells in the nasal area to complete its replication. The virus is then shed through the sheep's nasal secretions.

Now that they understand these viral changes, scientists can begin to find the right cell types to grow the virus in cell culture, according to Li.


Story Source:

The above story is based on materials provided by USDA/Agricultural Research Service. The original article was written by Sharon Durham. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sharon Durham. Figuring Out Puzzling Animal Diseases. Agricultural Research, April 2010 [link]

Cite This Page:

USDA/Agricultural Research Service. "Sheep virus life cycle that causes malignant catarrhal fever explained." ScienceDaily. ScienceDaily, 5 April 2010. <www.sciencedaily.com/releases/2010/04/100405122304.htm>.
USDA/Agricultural Research Service. (2010, April 5). Sheep virus life cycle that causes malignant catarrhal fever explained. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2010/04/100405122304.htm
USDA/Agricultural Research Service. "Sheep virus life cycle that causes malignant catarrhal fever explained." ScienceDaily. www.sciencedaily.com/releases/2010/04/100405122304.htm (accessed September 15, 2014).

Share This



More Plants & Animals News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Conservationists Face Uphill PR Battle With New Shark Rules

Conservationists Face Uphill PR Battle With New Shark Rules

Newsy (Sep. 14, 2014) New conservation measures for shark fishing face an uphill PR battle in the fight to slow shark extinction. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Lion Cubs the Pride of San Diego Zoo

Lion Cubs the Pride of San Diego Zoo

Reuters - US Online Video (Sep. 13, 2014) Roars of excitement as a proud lioness shows off her four cubs at the San Diego Zoo Safari Park. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins