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Oral Vaccine May Reduce Exacerbations in Patients with COPD

Date:
April 13, 2010
Source:
American College of Chest Physicians
Summary:
A novel vaccine may help reduce the number and severity of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).

A novel vaccine may help reduce the number and severity of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD).

Australian researchers developed a new oral immunotherapy (HI-164OV) using Haemophilus influenzae, the bacteria causing meningitis in children. In a randomized, multicenter, double blind, placebo-controlled trial, researchers tested the efficacy of the new vaccine and its effects on outcomes in 38 patients with severe COPD.

Results showed significant reductions in the areas of moderate to severe exacerbations (63 percent reduction), mean duration of episode (37 percent reduction), prescribed antibiotics (56 percent reduction), and exacerbations requiring hospital admission (90 percent reduction). No specific adverse effect was detected.

Researchers conclude that the vaccine shows potential in improving the health of patients with COPD.

The article is published in the April issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.


Story Source:

The above story is based on materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. K. Tandon, M. Phillips, G. Waterer, M. Dunkley, P. Comans, R. Clancy. Oral Immunotherapy with inactivated NTHi reduces severity of acute exacerbations in severe COPD. Chest, 2009; DOI: 10.1378/chest.09-1382

Cite This Page:

American College of Chest Physicians. "Oral Vaccine May Reduce Exacerbations in Patients with COPD." ScienceDaily. ScienceDaily, 13 April 2010. <www.sciencedaily.com/releases/2010/04/100406160430.htm>.
American College of Chest Physicians. (2010, April 13). Oral Vaccine May Reduce Exacerbations in Patients with COPD. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/04/100406160430.htm
American College of Chest Physicians. "Oral Vaccine May Reduce Exacerbations in Patients with COPD." ScienceDaily. www.sciencedaily.com/releases/2010/04/100406160430.htm (accessed April 19, 2014).

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