Featured Research

from universities, journals, and other organizations

Prescription drug could boost effects of vaccines for HIV and other diseases

Date:
May 7, 2010
Source:
American Chemical Society
Summary:
A prescription drug already approved to treat genital warts and skin cancer may have a new use in boosting the effectiveness of future vaccines for bacterial and viral diseases, such as hepatitis C and HIV.

A prescription drug already approved to treat genital warts and skin cancer may have a new use in boosting the effectiveness of future vaccines for bacterial and viral diseases, such as hepatitis C and HIV (the AIDS virus). These findings appear in ACS' Molecular Pharmaceutics, a bi-monthly journal.

John Pesce and colleagues at the Naval Medical Research Center and UC-Berkeley note that vaccines prepared from weakened or inactivated viruses or bacteria have had enormous success in preventing polio, influenza, and other diseases. However, vaccines containing living or weakened viruses cannot be used for HIV, hepatitis C, and other devastating diseases due to safety concerns.

Scientists are instead trying to develop a new generation of vaccines, made with DNA or proteins from infectious agents that can prevent illness without carrying a risk of causing the diseases. These vaccines will be weaker than conventional vaccines and require a new generation of "adjuvants," ingredients that boost a vaccine's immunogenicity.

The report identifies a promising candidate in the form of imiquimod, an immune-boosting drug already in general use. The scientists coated imiquimod with dextran-based microparticles in hopes of increasing the efficiency of cellular uptake by cells associated with immune response initiation. Sure enough, the coated drug significantly boosted levels of inflammatory cytokines in laboratory cultures of immune cells from mice. The findings have "broad significance" and open the door to more extensive testing of the approach, they indicate.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eric M. Bachelder, Tristan T. Beaudette, Kyle E. Broaders, Jean M. J. Fre%u0301chet, Mark T. Albrecht, Alfred J. Mateczun, Kristy M. Ainslie, John T. Pesce, Andrea M. Keane-Myers. In Vitro Analysis of Acetalated Dextran Microparticles as a Potent Delivery Platform for Vaccine Adjuvants. Molecular Pharmaceutics, 2010; 100401145321080 DOI: 10.1021/mp900311x

Cite This Page:

American Chemical Society. "Prescription drug could boost effects of vaccines for HIV and other diseases." ScienceDaily. ScienceDaily, 7 May 2010. <www.sciencedaily.com/releases/2010/05/100505113251.htm>.
American Chemical Society. (2010, May 7). Prescription drug could boost effects of vaccines for HIV and other diseases. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/05/100505113251.htm
American Chemical Society. "Prescription drug could boost effects of vaccines for HIV and other diseases." ScienceDaily. www.sciencedaily.com/releases/2010/05/100505113251.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins