Featured Research

from universities, journals, and other organizations

Discovery could aid development of elusive bovine mastitis vaccine

Date:
June 7, 2010
Source:
Biotechnology and Biological Sciences Research Council (BBSRC)
Summary:
Researchers have discovered components of the bovine mastitis-causing bacterium, Streptococcus uberis that play a key role in the disease. This discovery could lead the way to finally developing a vaccine for this endemic disease, which costs UK farmers alone nearly 200M per year, requires the large scale use of antibiotics, causes pain to cows and dramatically reduces milk yield.

Dairy cows grazing in a meadow.
Credit: iStockphoto/Chris Elwell

Researchers have discovered components of the bovine mastitis-causing bacterium, Streptococcus uberis that play a key role in the disease. This discovery could lead the way to finally developing a vaccine for this endemic disease, which costs UK farmers alone nearly 200M per year, requires the large scale use of antibiotics, causes pain to cows and dramatically reduces milk yield.

A solution to this problem will be an important contribution to the future security of our food supply in the UK. The research is due to be published in Veterinary Research.

BBSRC-funded researcher Professor James Leigh and his team from The University of Nottingham, along with colleagues at the Institute for Animal Health and the University of Oxford, have discovered that Streptococcus uberis -- a major cause of bovine mastitis -- uses the enzyme SrtA to anchor at its surface the proteins required for it to cause disease. They have also identified the individual anchored proteins that are required for the bacterium to withstand the responses within the udder that are trying to eliminate it.

Professor Leigh said: "What's really exciting about this is that we've discovered elements of one of the main culprits in bovine mastitis that could actually lead to a vaccine in the future.

"By identifying which components of the bacteria play a role in causing the disease, we can see exactly where to hit it with a vaccine to stop it ever becoming a problem."

At present bovine mastitis requires the large scale use of antibiotics to treat the disease and we know that this may lead to problems of antibiotic resistance down the line. Unfortunately, apart from good husbandry, there is little that can be done to prevent the disease at present.

The team is funded by the Biotechnology and Biological Sciences Research Council (BBSRC) under a scheme that aims to find sustainable ways to reduce the impact of endemic diseases of farm animals on the economy of UK farming industry and the welfare of animals that are kept for meat, eggs and dairy products. This is the BBSRC Combating Endemic Diseases of Farmed Animals for Sustainability (CEDFAS) initiative.

Professor Douglas Kell, BBSRC Chief Executive said: "To feed a growing global population we need to increase food production by 70% by 2050. We have to do this in a sustainable and ethical way and ensure that the UK farming industry remains strong. Endemic diseases of farm animals are extremely costly and cause significant welfare issues. This development is a welcome step towards preventing the suffering and losses associated with bovine mastitis."


Story Source:

The above story is based on materials provided by Biotechnology and Biological Sciences Research Council (BBSRC). Note: Materials may be edited for content and length.


Journal Reference:

  1. James A. Leigh, Sharon A. Egan, Philip N. Ward, Terrence R. Field, Tracey J. Coffey. Sortase anchored proteins of Streptococcus uberis play major roles in the pathogenesis of bovine mastitis in dairy cattle. Veterinary Research, 2010; 41 (5): 63 DOI: 10.1051/vetres/2010036

Cite This Page:

Biotechnology and Biological Sciences Research Council (BBSRC). "Discovery could aid development of elusive bovine mastitis vaccine." ScienceDaily. ScienceDaily, 7 June 2010. <www.sciencedaily.com/releases/2010/06/100607065902.htm>.
Biotechnology and Biological Sciences Research Council (BBSRC). (2010, June 7). Discovery could aid development of elusive bovine mastitis vaccine. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2010/06/100607065902.htm
Biotechnology and Biological Sciences Research Council (BBSRC). "Discovery could aid development of elusive bovine mastitis vaccine." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607065902.htm (accessed July 25, 2014).

Share This




More Plants & Animals News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How to Make Single Serving Smoothies: Howdini Hacks

How to Make Single Serving Smoothies: Howdini Hacks

Howdini (July 24, 2014) Smoothies are a great way to get in lots of healthy ingredients, plus they taste great! Howdini has a trick for making the perfect single-size smoothie that will save you time on cleanup too! All you need is a blender and a mason jar. Video provided by Howdini
Powered by NewsLook.com
Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Newsy (July 24, 2014) A new study claims a set of prehistoric T-Rex footprints supports the theory that the giant predators hunted in packs instead of alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins