Featured Research

from universities, journals, and other organizations

World's first plastic antibodies in live organisms: Stop spread of bee venom in mice

Date:
June 22, 2010
Source:
University of California - Irvine
Summary:
Researchers have developed the first "plastic antibodies" successfully employed in live organisms -- stopping the spread of bee venom through the bloodstream of mice.

"Plastic antibodies" that UCI scientists used to stop the spread of bee venom in mice could be designed to combat deadlier toxins and pathogens.
Credit: Photo by Hoang Xuan Pham / University Communications

UC Irvine researchers have developed the first "plastic antibodies" successfully employed in live organisms -- stopping the spread of bee venom through the bloodstream of mice.

Tiny polymeric particles -- just 1/50,000th the width of a human hair -- were designed to match and encase melittin, a peptide in bee venom that causes cells to rupture, releasing their contents. Large quantities of melittin can lead to organ failure and death.

The polymer nanoparticles were prepared by "molecular imprinting" a technique similar to plaster casting: UCI chemistry professor Kenneth Shea and project scientist Yu Hoshino linked melittin with small molecules called monomers, solidifying the two into a network of long polymer chains. After the plastic hardened, they removed the melittin, leaving nanoparticles with minuscule melittin-shaped holes.

When injected into mice given high doses of melittin, these precisely imprinted nanoparticles enveloped the matching melittin molecules, "capturing" them before they could disperse and wreak havoc -- greatly reducing deaths among the rodents.

"Never before have synthetic antibodies been shown to effectively function in the bloodstream of living animals," Shea says. "This technique could be utilized to make plastic nanoparticles designed to fight more lethal toxins and pathogens."

Takashi Kodama of Stanford University and Hiroyuki Koide, Takeo Urakami, Hiroaki Kanazawa and Naoto Oku of Japan's University of Shizuoka also contributed to the study, published recently in the Journal of the American Chemical Society.

Unlike natural antibodies produced by live organisms and harvested for medical use, synthetic antibodies can be created in laboratories at a lower cost and have a longer shelf life.

"The bloodstream includes a sea of competing molecules -- such as proteins, peptides and cells -- and presents considerable challenges for the design of nanoparticles," Shea says. "The success of this experiment demonstrates that these challenges can be overcome."


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yu Hoshino, Hiroyuki Koide, Takeo Urakami, Hiroaki Kanazawa, Takashi Kodama, Naoto Oku, Kenneth J. Shea. Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody. Journal of the American Chemical Society, 2010; 132 (19): 6644 DOI: 10.1021/ja102148f

Cite This Page:

University of California - Irvine. "World's first plastic antibodies in live organisms: Stop spread of bee venom in mice." ScienceDaily. ScienceDaily, 22 June 2010. <www.sciencedaily.com/releases/2010/06/100621141026.htm>.
University of California - Irvine. (2010, June 22). World's first plastic antibodies in live organisms: Stop spread of bee venom in mice. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2010/06/100621141026.htm
University of California - Irvine. "World's first plastic antibodies in live organisms: Stop spread of bee venom in mice." ScienceDaily. www.sciencedaily.com/releases/2010/06/100621141026.htm (accessed September 21, 2014).

Share This



More Plants & Animals News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins