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Can START stop cholesterol build-up?

Date:
June 24, 2010
Source:
The Biochemical Society
Summary:
A newly discovered group of proteins could help treat cholesterol build-up in arteries.
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A newly discovered group of proteins could help treat cholesterol build-up in arteries.

This build-up leads to atherosclerosis or 'hardening of the arteries', and the resulting condition, coronary heart disease, kills an estimated 124,000 each year in England and Wales.

In a paper in the latest issue of Clinical Science, Annette Graham and colleagues at Glasgow Caledonian University report on the use of steroidogenic acute regulatory protein-related lipid transfer (START) proteins to remove excess cholesterol from macrophage foam cells (cells that form obstacles in the arteries) and stop atherosclerotic lesions growing and even shrink them.

The most promising protein in the START family is STARD3 and this will be used in further experiments to see if it can form the basis for a therapy which will reduce cholesterol synthesis and build-up.


Story Source:

The above post is reprinted from materials provided by The Biochemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Faye Borthwick, Anne-Marie Allen, Janice M. Taylor, Annette Graham. Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype. Clinical Science, 2010; 119 (7): 265 DOI: 10.1042/CS20100266

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The Biochemical Society. "Can START stop cholesterol build-up?." ScienceDaily. ScienceDaily, 24 June 2010. <www.sciencedaily.com/releases/2010/06/100623085843.htm>.
The Biochemical Society. (2010, June 24). Can START stop cholesterol build-up?. ScienceDaily. Retrieved August 1, 2015 from www.sciencedaily.com/releases/2010/06/100623085843.htm
The Biochemical Society. "Can START stop cholesterol build-up?." ScienceDaily. www.sciencedaily.com/releases/2010/06/100623085843.htm (accessed August 1, 2015).

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