Featured Research

from universities, journals, and other organizations

Personalized approach to smoking cessation may be reality in 3-5 years

Date:
July 5, 2010
Source:
Duke University Medical Center
Summary:
A personalized approach to smoking cessation therapy is quickly taking shape. New evidence suggests that combining information about a smoker's genetic makeup with his or her smoking habits can accurately predict which nicotine replacement therapy will work best.

A personalized approach to smoking cessation therapy is quickly taking shape. New evidence from Duke University Medical Center and the National Institute on Drug Abuse (NIDA) suggests that combining information about a smoker's genetic makeup with his or her smoking habits can accurately predict which nicotine replacement therapy will work best.

"Within three to five years, it's conceivable we'll have a practical test that could take the guesswork out of choosing a smoking-cessation therapy," says Jed Rose, Ph.D., director of Duke's Center for Nicotine and Smoking Cessation Research. "It could be used by clinicians to guide the selection of treatment and appropriate dose for each smoker, and hopefully increase cessation success rates."

Statistics show 70 percent of the nation's 46 million smokers say they want to quit, yet successfully kicking the habit has not proven easy. In previously published reports, less than five percent of smokers who tried to quit on their own without any aids were not smoking one year later. Long-term quit rates for smokers who relied on pharmacological intervention hover under 25 percent.

The research, which is published online in the July-August issue of Molecular Medicine, follows previous work done by Rose and George Uhl, MD PhD, chief of the molecular neurobiology research at NIDA. After conducting a genome-wide scan of 520,000 genetic markers taken from blood samples of smokers in several quit-smoking trials, they identified genetic patterns that appear to influence how well individuals respond to specific smoking cessation treatments.

The latest research focuses on combining the information from those individual genetic markers, called SNPs, into one number that represents a "quit success score," Rose says. The score and the smokers' nicotine dependence, assessed via a simple questionnaire, help predict an individual's likelihood of quitting, as well as whether a high-dose or low-dose nicotine patch would work best.

In the trial, 479 cigarette smokers who smoked at least 10 cigarettes per day and wanted to quit were categorized as either high- or low-dependence based on their level of nicotine dependence. The smokers in each group were then randomly assigned to wear two nicotine skin patches daily delivering a high dose ( (42mg) or a standard dose (21 mg). Patches were worn for two weeks prior to their quit date, and the nicotine doses were reduced gradually over the 10 weeks following their quit date. Participants were given denicotinized cigarettes during the two weeks before the quit date to minimize any potential adverse effects from the high dose nicotine patches. The treatment phase lasted for 12 weeks in all.

DNA was extracted from participants' blood and was used to assess a quit-smoking success genetic score.

At six months follow up, the researchers were able to confirm which smokers fared better or worse on the high-dose compared to the low-dose patch.

"The genotype score was part of what predicted successful abstinence. In the future such a score could help us make our initial treatment decisions," said Rose. "People who had both high nicotine dependence and a low or unfavorable quit success genetic score seemed to benefit markedly from the high-dose nicotine patch, while people who had less dependence on nicotine did better on the standard patch."

Further studies are needed to replicate these results, and to expand the research to include therapies like verenicline (Chantix, Pfizer) and bupropion hydrochloride (Zyban, Glaxo SmithKline). But the potential this work holds for the future is significant, Rose says.

"Right now there is no treatment algorithm that tells a clinician or smoker which treatment is likely to work for them," says Rose. That's what we are trying to do. We want to tailor and give informative guidance to clinicians in terms of what should be tried first to maximize smoking cessation success."

This study was the result of a collaboration between an investigator supported by the National Institutes of Health (NIH) Intramural Research Program, National Institute on Drug Abuse, and Duke University researchers who received a grant from Philip Morris USA. The company had no role in the planning or execution of the study, data analysis or publication of results.

Disclosure: Drs. Uhl and Rose are listed as inventors for a patent application filed by Duke University based on genomic markers that distinguish successful quitters from unsuccessful quitters in data from other clinical trials.


Story Source:

The above story is based on materials provided by Duke University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jed E Rose, Frιdιrique M Behm, Tomas Drgon, Catherine Johnson, and George R Uhl. Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score. Molecular Medicine, 2010;

Cite This Page:

Duke University Medical Center. "Personalized approach to smoking cessation may be reality in 3-5 years." ScienceDaily. ScienceDaily, 5 July 2010. <www.sciencedaily.com/releases/2010/07/100702152415.htm>.
Duke University Medical Center. (2010, July 5). Personalized approach to smoking cessation may be reality in 3-5 years. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/07/100702152415.htm
Duke University Medical Center. "Personalized approach to smoking cessation may be reality in 3-5 years." ScienceDaily. www.sciencedaily.com/releases/2010/07/100702152415.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins