Featured Research

from universities, journals, and other organizations

Researchers identify factors behind blood-making stem cells

Date:
July 9, 2010
Source:
University of Montreal
Summary:
Researchers have made significant progress in the understanding of blood-producing (hematopoietic) stem cells. The study identifies factors that control the production of hematopoietic stem cells and offers interesting insight critical to the development of novel regenerative therapies and treatments for leukemia.

A team of researchers from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have made significant progress in the understanding of blood-producing (hematopoietic) stem cells. The study led by IRIC Chief Executive Officer and Scientific Director, Dr. Guy Sauvageau, identifies factors that control the production of hematopoietic stem cells.

Published in the journal Cell Stem Cell, the research offers interesting insight critical to the development of novel regenerative therapies and treatments for leukemia.

Hematopoietic stem cells (HSCs) are located within the bone marrow and serve as a reservoir for the production of all blood cells. A disruption in this process can have dire consequences leading either to a depleted blood cell population which can cause severe immune deficiencies, or excessive proliferation of blood cells which can trigger the development of leukemia. At the moment, relatively little is known about what controls this production.

The current study aims to understand the roles of various proteins that are present in HSCs and their impact on blood production. Researchers found that three proteins (Msi2, Pard6a and Prkcz) help blood cells to regenerate. That is, when HSCs lack these proteins, blood cells have a reduced capacity to regenerate themselves. Results from a fourth protein, Prox1, showed the reverse effect: their presence hinders the reproduction of blood cells.

"Understanding which proteins control the production of blood-making stem cells is crucial knowledge for designing therapies for diseases caused by unruly HSCs" explains Dr. Sauvageau, "Now that we recognize the key roles that these proteins play, we can evaluate their potential as therapeutic targets to treat a variety of diseases such as leukemia."

Dr. Guy Sauvageau holds the Canada Research Chair in the Molecular Genetics of Normal and Cancer Cells. The research received funding from the Canadian Institutes for Health Research.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristin J. Hope, Sonia Cellot, Stephen B. Ting, Tara MacRae, Nadine Mayotte, Norman N. Iscove, Guy Sauvageau. An RNAi Screen Identifies Msi2 and Prox1 as Having Opposite Roles in the Regulation of Hematopoietic Stem Cell Activity. Cell Stem Cell, 2010; 7 (1): 101 DOI: 10.1016/j.stem.2010.06.007

Cite This Page:

University of Montreal. "Researchers identify factors behind blood-making stem cells." ScienceDaily. ScienceDaily, 9 July 2010. <www.sciencedaily.com/releases/2010/07/100706150620.htm>.
University of Montreal. (2010, July 9). Researchers identify factors behind blood-making stem cells. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2010/07/100706150620.htm
University of Montreal. "Researchers identify factors behind blood-making stem cells." ScienceDaily. www.sciencedaily.com/releases/2010/07/100706150620.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins