Featured Research

from universities, journals, and other organizations

Specific oncogene plays a role in lung squamous cell carcinoma

Date:
August 13, 2010
Source:
Public Library of Science
Summary:
The identification of an oncogene specific to lung squamous cell carcinoma suggests that genetic activation of this oncogene could be used as an identification marker for this type of lung cancer.

The identification of an oncogene (called BRF2) specific to lung squamous cell carcinoma suggests that genetic activation of this oncogene could be used as an identification marker for this type of lung cancer. Furthermore, this oncogene may provide a new target for therapeutics for lung squamous cell carcinoma.

These findings come from a study by William Lockwood and colleagues from the BC Cancer Agency's Research Centre in Vancouver, Canada, and are reported in PLoS Medicine.

Lung cancer is the most common cause of cancer-related death, killing 1.3 million people every year worldwide. Most cases of lung cancer are "non-small cell lung cancers" of which there are 2 main types: squamous cell carcinoma and adenocarcinoma.

The authors used a comparative genetic hybridisation technique to show that the focal amplification of chromosome region 8p12 plays a role in the development of lung squamous cell carcinoma (in about 40% of cases) but not in the development of lung adenocarcinoma where DNA loss in this chromosomal region is the most common alteration. The oncogene BRF2 was frequently activated in pre-invasive stages of lung squamous cell carcinoma -- carcinoma in situ and dysplasia.

The authors conclude: "This is the first study, to our knowledge, to show that the focal amplification of a gene in chromosome 8p12 plays a key role in squamous cell lineage specificity of the disease. Our data suggest that genetic activation of BRF2 represents a unique mechanism of lung squamous cell carcinoma tumorgenesis." They add, "It [BRF2] can serve as a marker of lung squamous cell carcinoma and may provide a novel target for therapy."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lockwood WW, Chari R, et al. Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma. PLoS Medicine, 2010; 7 (7): e1000315 DOI: 10.1371/journal.pmed.1000315

Cite This Page:

Public Library of Science. "Specific oncogene plays a role in lung squamous cell carcinoma." ScienceDaily. ScienceDaily, 13 August 2010. <www.sciencedaily.com/releases/2010/07/100727174901.htm>.
Public Library of Science. (2010, August 13). Specific oncogene plays a role in lung squamous cell carcinoma. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/07/100727174901.htm
Public Library of Science. "Specific oncogene plays a role in lung squamous cell carcinoma." ScienceDaily. www.sciencedaily.com/releases/2010/07/100727174901.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins