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Specific oncogene plays a role in lung squamous cell carcinoma

Date:
August 13, 2010
Source:
Public Library of Science
Summary:
The identification of an oncogene specific to lung squamous cell carcinoma suggests that genetic activation of this oncogene could be used as an identification marker for this type of lung cancer.
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The identification of an oncogene (called BRF2) specific to lung squamous cell carcinoma suggests that genetic activation of this oncogene could be used as an identification marker for this type of lung cancer. Furthermore, this oncogene may provide a new target for therapeutics for lung squamous cell carcinoma.

These findings come from a study by William Lockwood and colleagues from the BC Cancer Agency's Research Centre in Vancouver, Canada, and are reported in PLoS Medicine.

Lung cancer is the most common cause of cancer-related death, killing 1.3 million people every year worldwide. Most cases of lung cancer are "non-small cell lung cancers" of which there are 2 main types: squamous cell carcinoma and adenocarcinoma.

The authors used a comparative genetic hybridisation technique to show that the focal amplification of chromosome region 8p12 plays a role in the development of lung squamous cell carcinoma (in about 40% of cases) but not in the development of lung adenocarcinoma where DNA loss in this chromosomal region is the most common alteration. The oncogene BRF2 was frequently activated in pre-invasive stages of lung squamous cell carcinoma -- carcinoma in situ and dysplasia.

The authors conclude: "This is the first study, to our knowledge, to show that the focal amplification of a gene in chromosome 8p12 plays a key role in squamous cell lineage specificity of the disease. Our data suggest that genetic activation of BRF2 represents a unique mechanism of lung squamous cell carcinoma tumorgenesis." They add, "It [BRF2] can serve as a marker of lung squamous cell carcinoma and may provide a novel target for therapy."


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The above post is reprinted from materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lockwood WW, Chari R, et al. Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma. PLoS Medicine, 2010; 7 (7): e1000315 DOI: 10.1371/journal.pmed.1000315

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Public Library of Science. "Specific oncogene plays a role in lung squamous cell carcinoma." ScienceDaily. ScienceDaily, 13 August 2010. <www.sciencedaily.com/releases/2010/07/100727174901.htm>.
Public Library of Science. (2010, August 13). Specific oncogene plays a role in lung squamous cell carcinoma. ScienceDaily. Retrieved August 1, 2015 from www.sciencedaily.com/releases/2010/07/100727174901.htm
Public Library of Science. "Specific oncogene plays a role in lung squamous cell carcinoma." ScienceDaily. www.sciencedaily.com/releases/2010/07/100727174901.htm (accessed August 1, 2015).

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