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Non-human primate study generates information relevant to HIV-1 vaccine strategies

Date:
August 6, 2010
Source:
Rockefeller University Press
Summary:
Monkeys repeatedly immunized with a particular form the HIV-1 envelope glycoprotein generated antibodies capable of neutralizing diverse strains of HIV-1, according to a paper published online in the Journal of Experimental Medicine on August 2.

Monkeys repeatedly immunized with a particular form the HIV-1 envelope glycoprotein generated antibodies capable of neutralizing diverse strains of HIV-1, according to a paper published online in the Journal of Experimental Medicine on August 2.

Antibodies in the blood of monkeys immunized with a HIV-1 envelope trimer neutralized a broader variety of HIV-1 strains than antibodies in the blood of humans immunized with an HIV-1 envelope monomer during the VAX04 phase III clinical trial.

However, the immunized monkeys showed only weak protection against subsequent rectal infection with a simian HIV virus. This weak protection may be due to the fact that neutralizing antibody titers were at least 1,000-fold lower in rectal and vaginal tissues than in the blood.

These findings suggest that methods to boost neutralizing antibody abundance in rectal and vaginal tissues might be needed to better prevent HIV-1 transmission.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher Sundling, Mattias N.E. Forsell, Sijy O'Dell, Yu Feng, Bimal Chakrabarti, Srinivas S. Rao, Karin Lorι, John R. Mascola, Richard T. Wyatt, Iyadh Douagi, and Gunilla B. Karlsson Hedestam. Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates. Journal of Experimental Medicine, 2010; DOI: 10.1084/jem.20100025

Cite This Page:

Rockefeller University Press. "Non-human primate study generates information relevant to HIV-1 vaccine strategies." ScienceDaily. ScienceDaily, 6 August 2010. <www.sciencedaily.com/releases/2010/08/100802125813.htm>.
Rockefeller University Press. (2010, August 6). Non-human primate study generates information relevant to HIV-1 vaccine strategies. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/08/100802125813.htm
Rockefeller University Press. "Non-human primate study generates information relevant to HIV-1 vaccine strategies." ScienceDaily. www.sciencedaily.com/releases/2010/08/100802125813.htm (accessed October 1, 2014).

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