Featured Research

from universities, journals, and other organizations

Microsoft Excel-based algorithm predicts cancer prognosis

Date:
September 2, 2010
Source:
BioMed Central
Summary:
Using readily available computer programs, researchers have developed a system to identify genes that will be useful in the classification of breast cancer. The algorithm will enable researchers to quickly generate valuable gene signatures without specialized software or extensive bioinformatics training.

Using readily available computer programs, researchers have developed a system to identify genes that will be useful in the classification of breast cancer. The algorithm, described in BioMed Central's open access Journal of Experimental & Clinical Cancer Research will enable researchers to quickly generate valuable gene signatures without specialized software or extensive bioinformatics training.

Robin Hallett, a graduate student working under the supervision of Dr. John Hassell and other members of his research team from McMaster University, Ontario, Canada, developed the algorithm and used it to identify a 20 gene signature, which performed well on a 151 patient validation dataset.

Hallett said, "Until now, constructing such a signature requires the use of various clustering and classification algorithms, which in turn require specialized software and bioinformatics training. Importantly, we completed all steps of our algorithm using Microsoft Excel 2007. This software is widely, if not universally, accessible to the biological research community, suggesting that implementation of this technique will not be hampered by lack of software or training."

The researchers used data from a group of 144 patients to train the algorithm to identify genes whose expression levels correlated with patient survival. The 10 most highly ranked genes predictive of poor prognosis and those 10 genes most highly predictive of good prognosis established a 20-gene expression based predictor, which was found to perform as well as two other models in the validation group.

According to Hassell, "Our algorithm produces prediction models with comparable accuracy to other feature selection techniques while having generally better accessibility and useability for biological research scientists. We've begun using our algorithm to generate gene expression based prediction models of breast cancer cell sensitivity to commonly used anti-cancer therapies."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robin M Hallett, Anna Dvorkin, Christine M Gabardo and John A Hassell. An algorithm to discover gene signatures with predictive potential. Journal of Experimental & Clinical Cancer Research, 2010; (in press)

Cite This Page:

BioMed Central. "Microsoft Excel-based algorithm predicts cancer prognosis." ScienceDaily. ScienceDaily, 2 September 2010. <www.sciencedaily.com/releases/2010/09/100901191135.htm>.
BioMed Central. (2010, September 2). Microsoft Excel-based algorithm predicts cancer prognosis. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2010/09/100901191135.htm
BioMed Central. "Microsoft Excel-based algorithm predicts cancer prognosis." ScienceDaily. www.sciencedaily.com/releases/2010/09/100901191135.htm (accessed April 17, 2014).

Share This



More Computers & Math News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Heartbleed Hack Leads To Arrest

Heartbleed Hack Leads To Arrest

Newsy (Apr. 17, 2014) A 19-year-old computer science student has been arrested in relation to a data breach of 900 social insurance numbers from Canada's revenue agency. Video provided by Newsy
Powered by NewsLook.com
Apple Rumored To Introduce Song ID Service In Next iOS Build

Apple Rumored To Introduce Song ID Service In Next iOS Build

Newsy (Apr. 17, 2014) Sources close to Apple told Bloomberg the company plans to introduce an integrated song identification service during the launch of its next iOS. Video provided by Newsy
Powered by NewsLook.com
Honda's New ASIMO Robot, More Human-Like Than Ever

Honda's New ASIMO Robot, More Human-Like Than Ever

AFP (Apr. 17, 2014) It walks and runs, even up and down stairs. It can open a bottle and serve a drink, and politely tries to shake hands with a stranger. Meet the latest ASIMO, Honda's humanoid robot. Duration: 00:54 Video provided by AFP
Powered by NewsLook.com
Yahoo's Ousted COO Gets $58M Severance Package

Yahoo's Ousted COO Gets $58M Severance Package

Newsy (Apr. 17, 2014) According to SEC filings, Yahoo gave ousted COO Henrique de Castro a $58 million severance package. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins