Featured Research

from universities, journals, and other organizations

Protein injection shows promise in lowering elevated triglycerides

Date:
October 22, 2010
Source:
American Heart Association
Summary:
A protein injection reduced high triglyceride levels in one type of genetically engineered mice, a new study has found. The approach might help people with similar genetic alterations that cause very high triglycerides.

Injecting a protein that helps break down triglycerides may someday help treat an inherited form of high triglycerides, according to a new study in Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal.

Related Articles


Triglyceride is a type of fat in the blood. Elevated levels in the blood -- hypertriglyceridemia -- have been linked to coronary artery disease. In the study, researchers tested a new compound in mice genetically altered to be deficient in a protein called apolipoprotein (apo)A-V, which causes them to have high blood levels of triglycerides. ApoA-V boosts the efficiency of lipoprotein lipase, an enzyme needed to break down triglycerides. The active compound consists of apoA-V complexed with phospholipid to form a reconstituted high density lipoprotein (HDL). The researchers administered the compound in the mice intravenously.

"We asked a simple question: If you just inject apoA-V into these mice that are lacking apoA-V and have very high levels of triglyceride, will it go down?" said Trudy Forte, Ph.D., study senior author and a scientist at Children's Hospital Oakland Research Institute in California. "We were very gratified to see that it went down, and it continued to do so over an eight-hour period."

By the end of the treatment, triglycerides had dropped about 87 percent.

However, in engineered mice lacking a protein called GPIHBP1, which also leads to very high triglycerides, the apoA-V injection didn't lower levels.

Intravenous apA-V may have a therapeutic benefit in humans with severely elevated triglycerides due to genetic changes that affect their levels of apoA-V, the researchers said.

Co-authors are: Xiao Shu, Ph.D.; Lisa Nelbach, Ph.D.; Michael M. Weinstein, Ph.D.; Braydon L. Burgess, M.S.; Jennifer A. Beckstead, M.S.; Stephen G. Young, M.D.; and Robert O. Ryan, Ph.D. Author disclosures and sources of funding are on the manuscript.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. X. Shu, L. Nelbach, M. M. Weinstein, B. L. Burgess, J. A. Beckstead, S. G. Young, R. O. Ryan, T. M. Forte. Intravenous Injection of Apolipoprotein A-V Reconstituted High-Density Lipoprotein Decreases Hypertriglyceridemia in apoav-/- Mice and Requires Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1. Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; DOI: 10.1161/ATVBAHA.110.210815

Cite This Page:

American Heart Association. "Protein injection shows promise in lowering elevated triglycerides." ScienceDaily. ScienceDaily, 22 October 2010. <www.sciencedaily.com/releases/2010/10/101021165233.htm>.
American Heart Association. (2010, October 22). Protein injection shows promise in lowering elevated triglycerides. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2010/10/101021165233.htm
American Heart Association. "Protein injection shows promise in lowering elevated triglycerides." ScienceDaily. www.sciencedaily.com/releases/2010/10/101021165233.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins