Featured Research

from universities, journals, and other organizations

Combining two types of antidepressants produces stronger effect; mouse study may help patients for whom existing antidepressants are not effective

Date:
November 16, 2010
Source:
Society for Neuroscience
Summary:
When it comes to antidepressants, two may be better than one. When drugs that alter two mood-regulating brain chemicals -- serotonin and acetylcholine -- are combined, they work together to produce a greater antidepressant response, a new animal study shows.

When it comes to antidepressants, two may be better than one. When drugs that alter two mood-regulating brain chemicals -- serotonin and acetylcholine -- are combined, they work together to produce a greater antidepressant response, a new animal study shows.

Related Articles


The research was presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience, held in San Diego.

"Although we have many therapies available to help alleviate the symptoms of depression, current treatments, which include the popular selective serotonin reuptake inhibitor [SSRI] medications, are effective in only about 50 percent of patients," said Marina Picciotto, PhD, of Yale University, the study's senior author. "Our study suggests that combination therapies could be beneficial in patients non-responsive to SSRIs," she said. SSRIs, which increase serotonin levels in the brain, have long been used to treat depression. More recently, animal studies and a few clinical trials have suggested that another brain chemical, acetycholine, plays an important role in regulating mood. Medicines that block some of the nerve receptors for acetylcholine can be antidepressant.

Picciotto and her colleagues found that combining the SSRI fluoxetine (Prozac) with cytisine, a drug that limits the effects of acetylcholine, produced greater antidepressant-like properties in mice than when the drugs were used alone. They also discovered that when serotonin was removed from the animals' brains, cytisine was no longer effective.

"This suggests that serotonin is critical for cytisine's antidepressant-like effects," Picciotto said.

Research was supported by the National Institute of Mental Health and NARSAD. Dr. Picciotto has a proprietary interest in developing several nicotinic partial agonists for the treatment of depression, none of which were used in the current study.


Story Source:

The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


Cite This Page:

Society for Neuroscience. "Combining two types of antidepressants produces stronger effect; mouse study may help patients for whom existing antidepressants are not effective." ScienceDaily. ScienceDaily, 16 November 2010. <www.sciencedaily.com/releases/2010/11/101116102126.htm>.
Society for Neuroscience. (2010, November 16). Combining two types of antidepressants produces stronger effect; mouse study may help patients for whom existing antidepressants are not effective. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/11/101116102126.htm
Society for Neuroscience. "Combining two types of antidepressants produces stronger effect; mouse study may help patients for whom existing antidepressants are not effective." ScienceDaily. www.sciencedaily.com/releases/2010/11/101116102126.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins