Featured Research

from universities, journals, and other organizations

Muscle cells point the finger at each other

Date:
November 24, 2010
Source:
Rockefeller University Press
Summary:
A new study reveals that muscle cells fuse together during development by poking "fingers" into each other to help break down the membranes separating them.

A new study reveals that muscle cells fuse together during development by poking "fingers" into each other to help break down the membranes separating them. The study appears online on November 22, 2010 in the Journal of Cell Biology.

During muscle development, individual muscle cells fuse together to form long myotubes containing multiple cell nuclei. In the fruit fly Drosophila melanogaster, fusion occurs between two different types of muscle cell: founder cells and fusion-competent myoblasts. Using electron microscopy to analyze developing fly embryos, Elizabeth Chen and colleagues from the Johns Hopkins University School of Medicine in Baltimore, MD, discovered that fusion-competent myoblasts send multiple "finger-like" protrusions into neighboring founder cells. These fingers contained large amounts of the cytoskeletal protein actin, and their formation required several proteins that stimulate the assembly of actin molecules into long filaments.

The actin-rich fingers helped form a small pore connecting the founder cell and fusion-competent myoblast, which gradually expands to fuse the two cell types together. The researchers think that the fingers assist pore formation by pushing the two cell membranes extremely close to each other.

The structure and behavior of these myoblast fingers are very similar to other types of actin-rich protrusions called invadosomes that researchers have previously identified in cancer cells and other cell types in culture. But this is the first example of this type of structure in a developing tissue. The researchers now want to investigate how these invasive myoblast fingers are formed and controlled.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristin L. Sens, Shiliang Zhang, Peng Jin, Rui Duan, Guofeng Zhang, Fengbao Luo, Lauren Parachini, and Elizabeth H. Chen. An Invasive Podosome-Like Structure Promotes Fusion Pore Formation During Myoblast Fusion. Journal of Cell Biology, November 22, 2010 DOI: 10.1083/jcb.201006006

Cite This Page:

Rockefeller University Press. "Muscle cells point the finger at each other." ScienceDaily. ScienceDaily, 24 November 2010. <www.sciencedaily.com/releases/2010/11/101122121631.htm>.
Rockefeller University Press. (2010, November 24). Muscle cells point the finger at each other. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/11/101122121631.htm
Rockefeller University Press. "Muscle cells point the finger at each other." ScienceDaily. www.sciencedaily.com/releases/2010/11/101122121631.htm (accessed October 23, 2014).

Share This



More Plants & Animals News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Working Mother DIY: Pumpkin Pom-Pom

Working Mother DIY: Pumpkin Pom-Pom

Working Mother (Oct. 22, 2014) How to make a pumpkin pom-pom. Video provided by Working Mother
Powered by NewsLook.com
San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

San Diego Zoo's White Rhinos Provide Hope for the Critically Endangered Species

Reuters - Light News Video Online (Oct. 22, 2014) The pair of rare white northern rhinos bring hope for their species as only six remain in the world. Elly Park reports. Video provided by Reuters
Powered by NewsLook.com
Raw: Bear Cub Strolls Through Oregon Drug Store

Raw: Bear Cub Strolls Through Oregon Drug Store

AP (Oct. 22, 2014) Shoppers at an Oregon drug store were surprised by a bear cub scurrying down the aisles this past weekend. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Family Pleads for Pet Pig to Stay at Home

Family Pleads for Pet Pig to Stay at Home

AP (Oct. 22, 2014) The Johnson family lost their battle with the Chesterfield County, Virginia Planning Commission to allow Tucker, their pet pig, to stay in their home, but refuse to let the board keep Tucker away. (Oct. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins