Featured Research

from universities, journals, and other organizations

Researchers show an oncolytic virus switches off cancer cell surival signal

Date:
December 1, 2010
Source:
Boston University Medical Center
Summary:
Researchers have identified a mechanism by which specific viruses acting as oncolytic agents can enter and kill cancer cells. This finding could help lead to the development of more targeted treatments against many types of cancer.

Researchers from Boston University School of Medicine (BUSM) have identified a mechanism by which specific viruses acting as oncolytic agents can enter and kill cancer cells. This finding, which is currently featured in an online edition of the Journal of Virology, could help lead to the development of more targeted treatments against many types of cancer.

Related Articles


The study was conducted by Ewan F. Dunn, a postdoctoral fellow, under the direction of John H. Connor, an assistant professor of microbiology at BUSM.

The virus, known as vesicular stomatitis virus (VSV), is being developed in the Connor lab and in other international research laboratories to kill cancer cells. VSV is not a significant human pathogen.

VSV is sensitive to the innate immune response, which causes lymphocytes to release interferon and protect the body from developing an infection. Cancer cells lose the ability to respond in that way, said Dunn. "When cancer cells transform, they become non-responsive, leaving them vulnerable to viruses attacking the cell and its function."

Previous research has shown that a major signaling pathway in cancer cells, called the AKT signaling pathway, is frequently turned on. AKT signaling is a cell survival signal, helping to keep the cancer cells alive. The team demonstrated was that VSV can switch off that signaling pathway, which suggests that a single viral protein could play a major role in cancer cell death.

"This study showed the important role of VSV in killing cancer cells through turning off a major survival signal," added Connor. "The identification of this mechanism is fundamental to understanding how VSV and other oncolytic viruses function."

This research study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. F. Dunn, J. H. Connor. Dominant Inhibition of Akt/PKB signaling by the Matrix protein of a negative-strand RNA virus. Journal of Virology, 2010; DOI: 10.1128/JVI.01671-10

Cite This Page:

Boston University Medical Center. "Researchers show an oncolytic virus switches off cancer cell surival signal." ScienceDaily. ScienceDaily, 1 December 2010. <www.sciencedaily.com/releases/2010/12/101201124351.htm>.
Boston University Medical Center. (2010, December 1). Researchers show an oncolytic virus switches off cancer cell surival signal. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/12/101201124351.htm
Boston University Medical Center. "Researchers show an oncolytic virus switches off cancer cell surival signal." ScienceDaily. www.sciencedaily.com/releases/2010/12/101201124351.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins