Featured Research

from universities, journals, and other organizations

Cellular power plants' 'import business' revealed

Date:
January 10, 2011
Source:
Albert-Ludwigs-Universität Freiburg
Summary:
Scientists in Germany have discovered a new signaling path in cells: a mechanism which enables the transport of proteins into mitochondria to be adjusted depending on the current metabolic state of the cell.

Scientists from Freiburg's two Excellence Institutions Centre for Biological Signalling Studies (BIOSS) and Spemann Graduate School of Biology and Medicine (SGBM) have discovered a new signaling path in cells: a mechanism which enables the transport of proteins into mitochondria to be adjusted depending on the current metabolic state of the cell.

The results of this study were published in the scientific journal Cell.

Mitochondria are the power plants of the cells. They transform energy taken up through nourishment into a form the cells can use for a multitude of necessary metabolic reactions. In addition, mitochondria are responsible for triggering programmed cell death. It has long been known that illnesses like diabetes, heart disease, and tumors can be traced back to dysfunctions in these cellular organelles. Mitochondria possess around 1,000 different proteins, most of which are initially produced in the cytosol. From there they are imported into the organelle.

A research team led by Prof. Dr. Chris Meisinger from the Institute of Biochemistry and Molecular Biology of the University of Freiburg has now discovered that the main port of entry for these proteins is changed in various ways by cytosolic signaling proteins depending on the metabolic state of the cell, thus regulating the intake of proteins into mitochondria. Mitochondria are descended from bacteria and still possess many of their characteristics today. Researchers were thus long convinced that these organelles act with a high degree of autonomy in higher cells, hardly communicating with other cellular compartments at all. The results of the research project suggest that many more communication paths between mitochondria and the rest of the cell are waiting to be discovered.

"Regulation of Mitochondrial Protein Import by Cytosolic Kinases." O. Schmidt, A. Harbauer, S. Rao, B. Eyrich, R. Zahedi, D. Stojanovski, B. Schönfisch, B. Guiard, A. Sickmann, N. Pfanner, and C. Meisinger.


Story Source:

The above story is based on materials provided by Albert-Ludwigs-Universität Freiburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Oliver Schmidt, Angelika B. Harbauer, Sanjana Rao, Beate Eyrich, René P. Zahedi, Diana Stojanovski, Birgit Schönfisch, Bernard Guiard, Albert Sickmann, Nikolaus Pfanner, and Chris Meisinger. Regulation of Mitochondrial Protein Import by Cytosolic Kinases. Cell, 2011; DOI: 10.1016/j.cell.2010.12.015

Cite This Page:

Albert-Ludwigs-Universität Freiburg. "Cellular power plants' 'import business' revealed." ScienceDaily. ScienceDaily, 10 January 2011. <www.sciencedaily.com/releases/2011/01/110107083755.htm>.
Albert-Ludwigs-Universität Freiburg. (2011, January 10). Cellular power plants' 'import business' revealed. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2011/01/110107083755.htm
Albert-Ludwigs-Universität Freiburg. "Cellular power plants' 'import business' revealed." ScienceDaily. www.sciencedaily.com/releases/2011/01/110107083755.htm (accessed September 18, 2014).

Share This



More Plants & Animals News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) — Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com
Chimp Violence Study Renews Debate On Why They Kill

Chimp Violence Study Renews Debate On Why They Kill

Newsy (Sep. 17, 2014) — The study weighs in on a debate over whether chimps are naturally violent or become that way due to human interference in the environment. Video provided by Newsy
Powered by NewsLook.com
Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) — The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) — Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins