Featured Research

from universities, journals, and other organizations

Measles viral protein movement described

Date:
January 10, 2011
Source:
Mayo Clinic
Summary:
Researchers have shown that proteins on the surface of a cell twist a viral protein into position, allowing the virus to start infection and cause disease, all in a movement as graceful as a ballroom dance.

Mayo Clinic researchers have shown that proteins on the surface of a cell twist a viral protein into position, allowing the virus to start infection and cause disease, all in a movement as graceful as a ballroom dance. The findings appear in the current online issue of Nature Structural & Molecular Biology.

Related Articles


A team led by Roberto Cattaneo, Ph.D., a Mayo molecular biologist, describes the crucial initial steps taken by attachment proteins of the measles virus and related respiratory viruses with their cellular partners, the receptors. To get there, the research team built "handles" at different locations on a viral attachment protein, allowing them to be grabbed by an artificial receptor to start the dance.

Visualize the measles virus. It is small and has an outer "envelope" with two proteins, one that interacts with a cellular receptor, its dance partner, and another that fuses the viral envelope with the cell membrane, starting infection.

Measles virus, while long targeted for eradication through vaccination, still affects 10 million people and kills some 197,000 each year around the world. A long-running question is how the cell entry process begins.

"It was known that the viral attachment proteins always come in pairs, and recently it became clear that two pairs form a quartet," Dr. Cattaneo says. "Pairs initially face each other, and we show here that the upper bodies separate when the dance begins. We suggest that they then engage a partner from the other pair of the quartet, while the legs are still dancing with those of the original partner."

As this dance continues, the cellular receptors weaken the layer of attachment proteins that protects a lower layer of fusion proteins. When enough quartets become twisted and unstable, the top layer fails abruptly. This failure causes unfolding of the proteins in the lower layer, and, in turn, fusion with the cellular membrane. The viral genome, now inside the cell, tells it to stop dividing and mandates the building of new viruses.

Dr. Cattaneo has studied viruses for three decades, primarily as tools for new medical discoveries. Viruses, he says, can be transformed into vectors to treat disease. In 1999, he joined Mayo Clinic as a founding member of the Molecular Medicine Department. To date, two viral vectors developed at Mayo Clinic are in clinical trials to treat ovarian cancer, glioma and myeloma.

Others on the team are Chanakha Navaratnarajah, Ph.D.; Levi Rupp; Leah Kay; and Vincent Leonard Ph.D., all of Mayo Clinic; and Numan Oezguen, Ph.D., and Werner Braun, Ph.D., from the University of Texas Medical Branch, Galveston. The research was supported by the National Institutes of Health and the Mayo Clinic Cancer Center.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chanakha K Navaratnarajah, Numan Oezguen, Levi Rupp, Leah Kay, Vincent H J Leonard, Werner Braun, Roberto Cattaneo. The heads of the measles virus attachment protein move to transmit the fusion-triggering signal. Nature Structural & Molecular Biology, 2011; DOI: 10.1038/nsmb.1967

Cite This Page:

Mayo Clinic. "Measles viral protein movement described." ScienceDaily. ScienceDaily, 10 January 2011. <www.sciencedaily.com/releases/2011/01/110109184017.htm>.
Mayo Clinic. (2011, January 10). Measles viral protein movement described. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/01/110109184017.htm
Mayo Clinic. "Measles viral protein movement described." ScienceDaily. www.sciencedaily.com/releases/2011/01/110109184017.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins