Featured Research

from universities, journals, and other organizations

Discovery of a gene associated with a leukemia mostly affecting children

Date:
January 18, 2011
Source:
Université du Québec à Montréal
Summary:
Researchers have made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. They have successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing cells that defend the body against infection.

Researchers in Montreal, Canada, have made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. They have successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing cells that defend the body against infection.

The findings, by Cyndia Charfi, a Ph. D student in biology at Université du Québec à Montréal (UQAM), supported by her thesis supervisors, Professor Éric Rassart, and Adjunct Professor Elsy Edouard, UQAM, Department of Biological Sciences and BIOMED Research Centre, were recently published in the journal Blood.

The research

Charfi first compared the transcriptome (the set of active genes in a cell) of leukemic and healthy mice. From this analysis, she was able to isolate groups of genes with abnormal activity in the leukemic mice. This led to the discovery that excessive synthesis of the Fmn2 gene and protein is associated with B-cell lymphocytic leukemia.

Although mice cells are genetically similar to human cells, they clearly are not identical. So the young researcher continued her work, this time using human cells. Her results were the same: abormal activity of Fmn2 gene was observed in human patients with B-cell lymphocytic leukemia and particularly in children.

Better diagnosis for better treatment

Leukemia refers to all cancers that attack the bone marrow cells. The bone marrow produces blood cells, hence the term "blood cancer." As there are several types of blood cells (including B-cells), there are also several types of leukemia, and the treatment differs for each type. The faster and more accurate the diagnosis of the type of leukemia, the better the treatment.

What is the significance of this discovery? According to Professor Rassart, "although it is basic research, Cyndia Charfi's findings represent a major advance and a step closer to improved diagnosis and, hopefully, treatment of this cancer, whose victims, we should recall, are mainly children."


Story Source:

The above story is based on materials provided by Université du Québec à Montréal. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. Charfi, V. Voisin, L.-C. Levros, E. Edouard, E. Rassart. Gene profiling of Graffi murine leukemia virus induced lymphoid leukemias: identification of leukemia markers and Fmn2 as a potential oncogene. Blood, 2010; DOI: 10.1182/blood-2010-10-311001

Cite This Page:

Université du Québec à Montréal. "Discovery of a gene associated with a leukemia mostly affecting children." ScienceDaily. ScienceDaily, 18 January 2011. <www.sciencedaily.com/releases/2011/01/110118113140.htm>.
Université du Québec à Montréal. (2011, January 18). Discovery of a gene associated with a leukemia mostly affecting children. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/01/110118113140.htm
Université du Québec à Montréal. "Discovery of a gene associated with a leukemia mostly affecting children." ScienceDaily. www.sciencedaily.com/releases/2011/01/110118113140.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins