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Discovery of a biochemical basis for broccoli's cancer-fighting ability

Date:
January 26, 2011
Source:
American Chemical Society
Summary:
Scientists are reporting discovery of a potential biochemical basis for the apparent cancer-fighting ability of broccoli and its veggie cousins. They found for the first time that certain substances in the vegetables appear to target and block a defective gene associated with cancer.

Broccoli. Scientists are reporting discovery of a potential biochemical basis for the apparent cancer-fighting ability of broccoli and its veggie cousins. They found for the first time that certain substances in the vegetables appear to target and block a defective gene associated with cancer.
Credit: iStockphoto

Scientists are reporting discovery of a potential biochemical basis for the apparent cancer-fighting ability of broccoli and its veggie cousins. They found for the first time that certain substances in the vegetables appear to target and block a defective gene associated with cancer.

Their report, which could lead to new strategies for preventing and treating cancer, appears in ACS' Journal of Medicinal Chemistry.

Fung-Lung Chung and colleagues showed in previous experiments that substances called isothiocyanates (or ITCs) -- found in broccoli, cauliflower, watercress, and other cruciferous vegetables -- appear to stop the growth of cancer. But nobody knew exactly how these substances work, a key to developing improved strategies for fighting cancer in humans. The tumor suppressor gene p53 appears to play a key role in keeping cells healthy and preventing them from starting the abnormal growth that is a hallmark of cancer. When mutated, p53 does not offer that protection, and those mutations occur in half of all human cancers. ITCs might work by targeting this gene, the report suggests.

The scientists studied the effects of certain naturally-occurring ITCs on a variety of cancer cells, including lung, breast and colon cancer, with and without the defective tumor suppressor gene. They found that ITCs are capable of removing the defective p53 protein but apparently leave the normal one alone. Drugs based on natural or custom-engineered ITCs could improve the effectiveness of current cancer treatments or lead to new strategies for treating and preventing cancer.

The authors acknowledged funding from the Ruth L. Kirschstein National Research Service Award and a grant from the National Cancer Institute of the National Institutes of Health.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiantao Wang, Anthony J. Di Pasqua, Sudha Govind, Erin McCracken, Charles Hong, Lixin Mi, Yuehua Mao, Jessie Yu-Chieh Wu, York Tomita, Jordan C. Woodrick, Robert L. Fine, Fung-Lung Chung. Selective Depletion of Mutant p53 by Cancer Chemopreventive Isothiocyanates and Their Structure−Activity Relationships. Journal of Medicinal Chemistry, 2011; 110111101729088 DOI: 10.1021/jm101199t

Cite This Page:

American Chemical Society. "Discovery of a biochemical basis for broccoli's cancer-fighting ability." ScienceDaily. ScienceDaily, 26 January 2011. <www.sciencedaily.com/releases/2011/01/110126131906.htm>.
American Chemical Society. (2011, January 26). Discovery of a biochemical basis for broccoli's cancer-fighting ability. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2011/01/110126131906.htm
American Chemical Society. "Discovery of a biochemical basis for broccoli's cancer-fighting ability." ScienceDaily. www.sciencedaily.com/releases/2011/01/110126131906.htm (accessed August 21, 2014).

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