Featured Research

from universities, journals, and other organizations

Reverse genetics allow scientists to slow spread of Rubella virus

Date:
February 18, 2011
Source:
Public Library of Science
Summary:
Scientists have identified the gene that allows the Rubella virus to block cell death and reverse engineered a mutant gene that slows the virus's spread. Researchers believed that RNA viruses were able to spread by blocking the pathways in cells that lead to cell suicide, and isolated the responsible gene in Rubella, also known as German measles.

Scientists have identified the gene that allows the Rubella virus to block cell death and reverse engineered a mutant gene that slows the virus's spread.

Tom Hobman and a team of researchers at the University of Alberta's Faculty of Medicine and Dentistry believed that RNA viruses were able to spread by blocking the pathways in cells that lead to cell suicide, and isolated the responsible gene in Rubella, also known as German measles. They then created a mutant version of this gene that made the virus spread more slowly. These results are reported in PLoS Pathogens.

The Rubella virus is responsible for more birth defects worldwide than any other infectious agent. More generally, RNA viruses also cause many viral diseases in humans, including AIDS, influenza, hepatitis C, West Nile disease and Dengue fever. If these findings are applicable to other viruses, it would give researchers more tools for preventing the rapid spread of disease.

Hobman and his colleagues discovered that a well-known protein in the Rubella virus blocked the process that triggers cell death -- allowing the virus to replicate and spread. The team then decided to conduct some reverse genetic experiments and mutated the capsid protein, which impaired the ability of the virus to replicate itself because cells would undergo cell suicide much earlier in the infection process and more often.

Hobman's team is now studying the West Nile and Dengue viruses to see if these RNA viruses prevent cell suicide in the same way. He hopes the discovery will one day lead to viral infections being limited and shutdown at an earlier stage.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carolina S. Ilkow, Ing Swie Goping, Tom C. Hobman. The Rubella Virus Capsid Is an Anti-Apoptotic Protein that Attenuates the Pore-Forming Ability of Bax. PLoS Pathogens, 2011; 7 (2): e1001291 DOI: 10.1371/journal.ppat.1001291

Cite This Page:

Public Library of Science. "Reverse genetics allow scientists to slow spread of Rubella virus." ScienceDaily. ScienceDaily, 18 February 2011. <www.sciencedaily.com/releases/2011/02/110217171338.htm>.
Public Library of Science. (2011, February 18). Reverse genetics allow scientists to slow spread of Rubella virus. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/02/110217171338.htm
Public Library of Science. "Reverse genetics allow scientists to slow spread of Rubella virus." ScienceDaily. www.sciencedaily.com/releases/2011/02/110217171338.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Adorable Video of Baby Rhino and Lamb Friend Playing

Adorable Video of Baby Rhino and Lamb Friend Playing

Buzz60 (Oct. 20, 2014) Gertjie the Rhino and Lammie the Lamb are teaching the world about animal conservation and friendship. TC Newman (@PurpleTCNewman) has the adorable video! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins