Featured Research

from universities, journals, and other organizations

Stem cell study could aid motor neuron disease research

Date:
March 7, 2011
Source:
University of Edinburgh
Summary:
Scientists have discovered a new way to generate human motor nerve cells in a development that will help research into motor neuron disease. Scientists have created a range of motor neurons -- nerves cells that send messages from the brain and spine to other parts of the body -- from human embryonic stem cells in the laboratory.

Scientists have discovered a new way to generate human motor nerve cells in a development that will help research into motor neuron disease.

Related Articles


A team from the Universities of Edinburgh, Cambridge and Cardiff has created a range of motor neurons -- nerves cells that send messages from the brain and spine to other parts of the body -- from human embryonic stem cells in the laboratory.

It is the first time that researchers have been able to generate a variety of human motor neurons, which differ in their make-up and display properties depending on where they are located in the spinal cord.

The research, published in the journal Nature Communications, could help scientists better understand motor neuron disease. The process will enable scientists to create different types of motor neurons and study why some are more vulnerable to disease than others.

Motor neurons control muscle activity such as speaking, walking, swallowing and breathing. However, in motor neuron disease -- a progressive and ultimately fatal disorder -- these cells break down leading to paralysis, difficulty speaking, breathing and swallowing.

Previously scientists had only been able to generate one particular kind of motor neuron, which they did by using retinoic acid, a vitamin A derivative.

In the latest study, scientists have found a way to generate a wider range of motor neurons using a new process without retinoic acid.

Professor Siddharthan Chandran, Director of the Euan MacDonald Centre for Motor Neurone Disease Research at the University of Edinburgh, said: "Motor neurons differ in their make-up, so understanding why some are more vulnerable than others to disease is important for developing treatment for this devastating condition."

Dr Rickie Patani, of the University of Cambridge, said: "Although motor neurons are often considered as a single group, they represent a diverse collection of neuronal subtypes. The ability to create a range of different motor neurons is a key step in understanding the basis of selective subtype vulnerability in conditions such as motor neuron disease and spinal muscular atrophy."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Patani, A. J. Hollins, T. M. Wishart, C. A. Puddifoot, S. Αlvarez, A. R. de Lera, D. J. A. Wyllie, D. A. S. Compston, R. A. Pedersen, T. H. Gillingwater, et al. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state open. Nature Communications, 2, 214 DOI: 10.1038/ncomms1216

Cite This Page:

University of Edinburgh. "Stem cell study could aid motor neuron disease research." ScienceDaily. ScienceDaily, 7 March 2011. <www.sciencedaily.com/releases/2011/03/110301122047.htm>.
University of Edinburgh. (2011, March 7). Stem cell study could aid motor neuron disease research. ScienceDaily. Retrieved January 25, 2015 from www.sciencedaily.com/releases/2011/03/110301122047.htm
University of Edinburgh. "Stem cell study could aid motor neuron disease research." ScienceDaily. www.sciencedaily.com/releases/2011/03/110301122047.htm (accessed January 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, January 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
This Is What It's Like To Date A Med Student

This Is What It's Like To Date A Med Student

BuzzFeed (Jan. 23, 2015) — Dating is now speed-dating... or studying. Video provided by BuzzFeed
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins