Featured Research

from universities, journals, and other organizations

Road traffic pollution doubles risk of rejection after lung transplant

Date:
March 24, 2011
Source:
BMJ-British Medical Journal
Summary:
Lung transplant patients have double the risk of organ rejection and death within five years of the procedure if they live near a main road, new research indicates.

Lung transplant patients have double the risk of organ rejection and death within five years of the procedure if they live near a main road, indicates research published online in Thorax.

The Belgian researchers tracked the health of 281 patients who had undergone a lung transplant or retransplant at the same hospital between 1997 and 2008 until 2009.

They took into account how far these patients lived from a main road and therefore a source of airborne road traffic pollution to see if this had any impact on their survival rates, as pollutants are known to trigger inflammation.

Around half of all patients who undergo a lung transplant develop a serious inflammatory condition called bronchiolitis obliterans syndrome within five years of having the procedure, say the authors.

The syndrome, which is caused by an overactive immune system, is the clinical equivalent of organ rejection and is considerably more common in lung transplant recipients than it is in other solid organ transplant patients -- possibly because of the lung's direct contact with the environment, they add.

During the monitoring period, 117 patients (41%) developed the syndrome, one in five of whom (61) died.

Gender, age, or type of transplantation (single or double) had no bearing on the risk of death, the findings showed. But a clear pattern emerged for proximity to a main road.

Those who lived within a 171 metre radius of a main road were twice as likely to develop the syndrome and more than twice as likely to die as their peers who lived further away from this source of pollution.

Furthermore, the calculations showed that for every 10-fold increase in distance from a main road, patients were 43% less likely to develop the syndrome and 28% less likely to die.

Lung lavages (washing out of the lungs) and blood samples taken from 207 lung transplant recipients also showed that levels of inflammatory markers were associated with distance from a main road: the greater the distance from a main road, the lower they were.

The findings prompt the authors to conclude that one in four cases of bronchiolitis obliterans syndrome and almost 30% (28%) of deaths in lung transplant recipients across the country could be attributed to living near a major road.

"These population attributable fractions are significant not only in terms of patient suffering but also in terms of healthcare costs," say the authors. "Traffic related air pollution appears to constitute a serious risk ... If confirmed by other studies, [it] has substantial clinical and public health implications."


Story Source:

The above story is based on materials provided by BMJ-British Medical Journal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tim S Nawrot, Robin Vos, Lotte Jacobs, Stijn E Verleden, Shana Wauters, Veerle Mertens, Christophe Dooms, Peter H Hoet, Dirk E Van Raemdonck, Christel Faes, Lieven J Dupont, Benoit Nemery, Geert M Verleden, Bart M Vanaudenaerde. The impact of traffic air pollution on bronchiolitis obliterans syndrome and mortality after lung transplantation. Thorax, 2011; DOI: 10.1136/thx.2010.155192

Cite This Page:

BMJ-British Medical Journal. "Road traffic pollution doubles risk of rejection after lung transplant." ScienceDaily. ScienceDaily, 24 March 2011. <www.sciencedaily.com/releases/2011/03/110323192955.htm>.
BMJ-British Medical Journal. (2011, March 24). Road traffic pollution doubles risk of rejection after lung transplant. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/03/110323192955.htm
BMJ-British Medical Journal. "Road traffic pollution doubles risk of rejection after lung transplant." ScienceDaily. www.sciencedaily.com/releases/2011/03/110323192955.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins