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Giant fire-bellied toad's brain brims with powerful germ-fighters

Date:
April 13, 2011
Source:
American Chemical Society
Summary:
Frog and toad skins already are renowned as cornucopias of hundreds of germ-fighting substances. Now a new report reveals that the toad brains also may contain an abundance of antibacterial and antiviral substances that could inspire a new generation of medicines.

Frog and toad skins already are renowned as cornucopias of hundreds of germ-fighting substances. Now a new report in ACS's Journal of Proteome Research reveals that the toad brains also may contain an abundance of antibacterial and antiviral substances that could inspire a new generation of medicines.

Ren Lai and colleagues point out that scientists know little about the germ-fighting proteins in amphibian brains, despite many studies showing that amphibians synthesize and secrete a remarkably diverse array of antimicrobial substances in their skin. So they decided to begin filling that knowledge gap by analyzing brains from the Giant Fire-Bellied Toad and the Small-webbed Bell Toad.

They discovered 79 different antimicrobial peptides, the components of proteins, including 59 that were totally new to science. The diversity of the peptides "is, to our knowledge, the most extreme yet described for any animal brains," they noted. Some of the peptides showed strong antimicrobial activity, crippling or killing strains of staph bacteria, E. coli, and the fungus that causes yeast infections in humans. These promising findings suggest that the toad brains might be a valuable source for developing new antibacterial and antiviral drugs.

The researchers acknowledge funding from the Chinese National Natural Science Foundation and the Ministry of Science and Technology.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rui Liu, Huan Liu, Yufang Ma, Jing Wu, Hailong Yang, Huahu Ye, Ren Lai. There are Abundant Antimicrobial Peptides in Brains of Two Kinds ofBombinaToads. Journal of Proteome Research, 2011; 10 (4): 1806 DOI: 10.1021/pr101285n

Cite This Page:

American Chemical Society. "Giant fire-bellied toad's brain brims with powerful germ-fighters." ScienceDaily. ScienceDaily, 13 April 2011. <www.sciencedaily.com/releases/2011/04/110413121010.htm>.
American Chemical Society. (2011, April 13). Giant fire-bellied toad's brain brims with powerful germ-fighters. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2011/04/110413121010.htm
American Chemical Society. "Giant fire-bellied toad's brain brims with powerful germ-fighters." ScienceDaily. www.sciencedaily.com/releases/2011/04/110413121010.htm (accessed September 1, 2014).

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