Featured Research

from universities, journals, and other organizations

Drug development speeds up with more advanced microarray technology

Date:
April 21, 2011
Source:
Technical Research Centre of Finland (VTT)
Summary:
RNA interference technology, which is used in cell biology, has revolutionized functional research of the gene products in the last ten years. Now researchers have developed a method which allows a single microchip to be used to screen the functions of tens of thousands of genes simultaneously by means of RNA interference. Traditional methods only allow a few hundred genes to be screened with each microplate.

RNA interference technology, which is used in cell biology, has revolutionised functional research of the gene products in the last ten years. VTT Technical Research Centre of Finland has developed a method which allows a single microchip to be used to screen the functions of tens of thousands of genes simultaneously by means of RNA interference. Traditional methods only allow a few hundred genes to be screened with each microplate, and therefore the new method will accelerate VTT's service offering in the field of drug development.

"VTT has already tested the method on a panel of almost one hundred cancer cell types and found it to be both efficient and reliable. We have used the method especially in breast cancer and prostate cancer studies," explains Juha Rantala, a research scientist at VTT and the founder of the method.

The primary benefit of the method is that it allows such a large number of samples to be analysed simultaneously, which saves both money and human resources, and speeds up research considerably. The findings of the study were published in March 2011 in BMC Genomics, a journal specialising in the methodologies of genetic research.

Miniaturised cell spot microarray techniques, which are used to analyse the functioning of cells, have featured in drug development at VTT for a few years now, and they are both an important research tool and a development priority. Ultra-high throughput screening (UHTS) techniques are used at VTT to study how one gene or groups of genes regulate the cell activities, and how the cell functions promote health, or cause illnesses. RNA interference technology allows genes to be "silenced" and thereby inhibit protein production of genes. Potential future use of RNAi technology includes also the diagnosis and treatment of illnesses.

The unique method developed by VTT is mostly used in genomic-scale analyses which have previously been very expensive. The new technology is believed to give VTT a competitive advantage in genome research which is of special interest of the drug industry. Other potential applications include studying the combined effects of genes and drugs. Research scientists at VTT have also cited the method previously in a scientific publication focusing on the cell division of breast cancer cells. The method is believed to significantly boost VTT's commercial activities with the drug industry.


Story Source:

The above story is based on materials provided by Technical Research Centre of Finland (VTT). Note: Materials may be edited for content and length.


Journal Reference:

  1. Juha K Rantala, Rami Mไkelไ, Anna-Riina Aaltola, Petra Laasola, John-Patrick Mpindi, Matthias Nees, Petri Saviranta, Olli Kallioniemi. A cell spot microarray method for production of high density siRNA transfection microarrays. BMC Genomics, 2011; 12 (1): 162 DOI: 10.1186/1471-2164-12-162

Cite This Page:

Technical Research Centre of Finland (VTT). "Drug development speeds up with more advanced microarray technology." ScienceDaily. ScienceDaily, 21 April 2011. <www.sciencedaily.com/releases/2011/04/110420081813.htm>.
Technical Research Centre of Finland (VTT). (2011, April 21). Drug development speeds up with more advanced microarray technology. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/04/110420081813.htm
Technical Research Centre of Finland (VTT). "Drug development speeds up with more advanced microarray technology." ScienceDaily. www.sciencedaily.com/releases/2011/04/110420081813.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) — The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins