Featured Research

from universities, journals, and other organizations

Stem cell study could pave the way to treatment for age-related muscle wasting

Date:
May 17, 2011
Source:
Monash University
Summary:
Biologists have nailed the mechanism that causes stem cells in the embryo to differentiate into specialized cells that form the skeletal muscles of animals' bodies.

A team led by developmental biologist Professor Christophe Marcelle has nailed the mechanism that causes stem cells in the embryo to differentiate into specialized cells that form the skeletal muscles of animals' bodies. The scientists published their results in the British journal Nature on May 16.

Scientists world wide are racing to pin down the complex molecular processes that cause stem cells in the early embryo to differentiate into specialist cells such as muscle or nerve cells. The field has the potential to revolutionzse medicine by delivering therapies to regenerate tissue damaged by disease or injury.

Differentiation happens soon after fertilization, when embryonic cells are dividing rapidly and migrating as the animal's body takes shape.

Professor Marcelle's team analyzed the differentiation of muscle stem cells in chicken embryos. The mechanisms in birds are identical to those in mammals, so the chick is a good model species for understanding the mechanisms in humans, says team member and the paper's lead author, Anne Rios.

The scientists investigated the effect of a known signaling pathway called NOTCH on muscle differentiation. They found that differentiation of stem cells to muscle was initiated when NOTCH signaling proteins touched some of the cells. These proteins were carried by passing cells migrating from a different tissue-the neural crest-the progenitor tissue of sensory nerve cells. Muscle formation in the target stem cells occurred only when the NOTCH pathway was triggered briefly by the migrating neural crest cells.

"This kiss-and-run activation of a pathway is a completely novel mechanism of stem cell specification which explains why only some stem cells adopt a muscle cell fate," Ms Rios said.

Professor Marcelle said that more than 2 per cent of the population was affected by muscle dysfunction. "Muscle frailty in aging and disease imposes a huge economic burden, so it is critical to explore novel avenues of research that could lead to new treatments," he said.

He said the team would now focus on unraveling the mechanisms of embryonic muscle cell differentiation at the molecular level as a necessary step to regulating regeneration of the muscles in human patients.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anne C. Rios, Olivier Serralbo, David Salgado, Christophe Marcelle. Neural crest regulates myogenesis through the transient activation of NOTCH. Nature, 2011; DOI: 10.1038/nature09970

Cite This Page:

Monash University. "Stem cell study could pave the way to treatment for age-related muscle wasting." ScienceDaily. ScienceDaily, 17 May 2011. <www.sciencedaily.com/releases/2011/05/110517105806.htm>.
Monash University. (2011, May 17). Stem cell study could pave the way to treatment for age-related muscle wasting. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2011/05/110517105806.htm
Monash University. "Stem cell study could pave the way to treatment for age-related muscle wasting." ScienceDaily. www.sciencedaily.com/releases/2011/05/110517105806.htm (accessed April 23, 2014).

Share This



More Plants & Animals News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Leopard Bites Man in India

Raw: Leopard Bites Man in India

AP (Apr. 22, 2014) A leopard caused panic in the city of Chandrapur on Monday when it sprung from the roof of a house and charged at rescue workers. (April 22) Video provided by AP
Powered by NewsLook.com
Iowa College Finds Beauty in Bulldogs

Iowa College Finds Beauty in Bulldogs

AP (Apr. 22, 2014) Drake University hosts 35th annual Beautiful Bulldog Contest. (April 21) Video provided by AP
Powered by NewsLook.com
805-Pound Shark Caught Off The Coast Of Florida

805-Pound Shark Caught Off The Coast Of Florida

Newsy (Apr. 22, 2014) One Florida fisherman caught a 805-pound shark off the coast of Florida earlier this month. Video provided by Newsy
Powered by NewsLook.com
Breakfast Foods Are Getting Pricier

Breakfast Foods Are Getting Pricier

AP (Apr. 21, 2014) Breakfast is now being served with a side of sticker shock. The cost of morning staples like bacon, coffee and orange juice is on the rise because of global supply problems. (April 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins