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Mushroom compound suppresses prostate tumors

Date:
May 24, 2011
Source:
Queensland University of Technology
Summary:
A mushroom used in Asia for its medicinal benefits has been found to be 100 percent effective in suppressing prostate tumor development in mice during early trials, new research shows.

Dr Patrick Ling says this is the first time the PSP compound has been shown to have anti-cancer stem cell effects.
Credit: Image courtesy of Queensland University of Technology

A mushroom used in Asia for its medicinal benefits has been found to be 100 per cent effective in suppressing prostate tumour development in mice during early trials, new Queensland University of Technology (QUT) research shows.

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The compound, polysaccharopeptide (PSP), which is extracted from the 'turkey tail' mushroom, was found to target prostate cancer stem cells and suppress tumour formation in mice, according to an article written by senior research fellow Dr Patrick Ling in the online journal PLoS ONE, published by the Public Library of Science.

Dr Ling, from the Australian Prostate Cancer Research Centre-Queensland and Institute for Biomedical Health & Innovation (IHBI) at QUT, said the results could be an important step towards fighting a disease that kills 3,000 Australian men a year.

"The findings are quite significant," Dr Ling said.

"What we wanted to demonstrate was whether that compound could stop the development of prostate tumours in the first place.

"In the past, other inhibitors tested in research trials have been shown to be up to 70 per cent effective, but we're seeing 100 per cent of this tumour prevented from developing with PSP.

"Importantly, we did not see any side effects from the treatment."

Dr Ling said conventional therapies were only effective in targeting certain cancer cells, not cancer stem cells, which initiated cancer and caused the disease to progress.

During the research trial, which was done in collaboration with The University of Hong Kong and Provital Pty Ltd, transgenic mice that developed prostate tumours were fed PSP for 20 weeks.

Dr Ling said no tumours were found in any of the mice fed PSP, whereas mice not given the treatment developed prostate tumours. He said the research suggested that PSP treatment could completely inhibit prostate tumour formation.

"Our findings support that PSP may be a potent preventative agent against prostate cancer, possibly through targeting of the prostate cancer stem cell population," he said.

He said PSP had been previously shown to possess anti-cancer properties, and 'turkey tail' mushrooms (known as Coriolus versicolor or Yun-zhi) had been widely used in Asia for medicinal benefits.

However, Dr Ling said it was the first time it had been demonstrated that PSP had anti-cancer stem cell effects.

Although 'turkey tail' mushrooms had valuable health properties, Dr Ling said it would not be possible to get the same benefit his research showed from simply eating them.

A fundraiser has been organised in September to support further tests for the therapeutic potential of PSP against prostate tumours either alone or in combination with other anti-cancer compounds.


Story Source:

The above story is based on materials provided by Queensland University of Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sze-Ue Luk, Terence Kin-Wah Lee, Ji Liu, Davy Tak-Wing Lee, Yung-Tuen Chiu, Stephanie Ma, Irene Oi-Lin Ng, Yong-Chuan Wong, Franky Leung Chan, Ming-Tat Ling. Chemopreventive Effect of PSP Through Targeting of Prostate Cancer Stem Cell-Like Population. PLoS ONE, 2011; 6 (5): e19804 DOI: 10.1371/journal.pone.0019804

Cite This Page:

Queensland University of Technology. "Mushroom compound suppresses prostate tumors." ScienceDaily. ScienceDaily, 24 May 2011. <www.sciencedaily.com/releases/2011/05/110523091539.htm>.
Queensland University of Technology. (2011, May 24). Mushroom compound suppresses prostate tumors. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/05/110523091539.htm
Queensland University of Technology. "Mushroom compound suppresses prostate tumors." ScienceDaily. www.sciencedaily.com/releases/2011/05/110523091539.htm (accessed October 25, 2014).

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