Featured Research

from universities, journals, and other organizations

Intravenous nutrition for critically ill patients must not be administered too early, Belgian study finds

Date:
July 1, 2011
Source:
Katholieke Universiteit Leuven
Summary:
Intravenous nutrition does not have a positive effect on the recovery of critically ill patients if it is administered early, according to new research from Belgium. Recovery from critical illness is in fact faster when patients receive supplementary intravenous nutrition one week after their admission to intensive care.

Intravenous nutrition does not have a positive effect on the recovery of critically ill patients if it is administered early, according to new research from Belgium. Recovery from critical illness is in fact faster when patients receive supplementary intravenous nutrition one week after their admission to intensive care.

Related Articles


Critically ill patients receive intravenous nutrition -- via an infusion in a large vein -- when nutrition via a stomach or intestinal tube is insufficient. There is international dispute over the correct timing of intravenous nutrition: European guidelines recommend administering intravenous nutrition within 48 hours to prevent malnutrition. In the United States and Canada, intravenous nutrition is administered after 8 days because it also has disadvantages, such as increased blood sugar levels. Because the food is administered directly into the blood, there is no natural reflex to balance the blood sugar level. Increased blood sugar levels damage cells in critically ill patients.

In a study led by Professor Greet Van den Berghe and Dr. Michael Casaer of the Department of Intensive Care Medicine at K.U. Leuven, 4,640 patients were monitored and treated in seven intensive care units in Leuven and Hasselt. The two systems of intravenous nutrition were compared, while elevated blood sugar levels were avoided with insulin.

Despite the very limited intake of food, patients who only received intravenous nutrition after a week had a greater chance of leaving the intensive care unit more quickly and without complications. They had fewer infections and reacted more efficiently to them, spent less time on respirators or dialysis machines and had fewer liver problems. As a result, the patients recovered more quickly.

According to professor Van den Berghe, the explanation is to be found in the natural cleaning system of the cells. "Critical illness causes damage to the cells of all vital organ systems. Damaged mitochondria -- energy factories in cells -- and functional proteins can only be cleared by autophagy: a cleaning system that is activated by fasting and which is suppressed by feeding. In additional experimental research, we demonstrated that a lack of food during the first week of serious illness improves the clearing of such cell damage."


Story Source:

The above story is based on materials provided by Katholieke Universiteit Leuven. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael P. Casaer, Dieter Mesotten, Greet Hermans, Pieter J. Wouters, Miet Schetz, Geert Meyfroidt, Sophie Van Cromphaut, Catherine Ingels, Philippe Meersseman, Jan Muller, Dirk Vlasselaers, Yves Debaveye, Lars Desmet, Jasperina Dubois, Aime Van Assche, Simon Vanderheyden, Alexander Wilmer, Greet Van den Berghe. Early versus Late Parenteral Nutrition in Critically Ill Adults. New England Journal of Medicine, 2011; 110629140038061 DOI: 10.1056/NEJMoa1102662

Cite This Page:

Katholieke Universiteit Leuven. "Intravenous nutrition for critically ill patients must not be administered too early, Belgian study finds." ScienceDaily. ScienceDaily, 1 July 2011. <www.sciencedaily.com/releases/2011/07/110701082804.htm>.
Katholieke Universiteit Leuven. (2011, July 1). Intravenous nutrition for critically ill patients must not be administered too early, Belgian study finds. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2011/07/110701082804.htm
Katholieke Universiteit Leuven. "Intravenous nutrition for critically ill patients must not be administered too early, Belgian study finds." ScienceDaily. www.sciencedaily.com/releases/2011/07/110701082804.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins