Featured Research

from universities, journals, and other organizations

New clues to the structural dynamics of BK channels

Date:
July 14, 2011
Source:
Rockefeller University Press
Summary:
BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows that BK channel activation involves structural rearrangements formerly not understood.

BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows that BK channel activation involves structural rearrangements formerly not understood.

Related Articles


The study appears in the August 2011 issue of the Journal of General Physiology.

Previous research pointed to a possible unified theory of activation gating in K+ channels, with the "activation gate" formed by the bundle crossing of four S6 transmembrane helices from the four subunits. Recent studies, however, have suggested a different structure for BK channels, but the exact location of the activation gate remained a mystery.

A new study by Xixi Chen and Richard Aldrich (The University of Texas at Austin) provides important clues to this question. The research identifies a single residue M314, halfway down S6, that appears to change conformation during the opening of the BK channel, rotating its side chain from a position in the closed state not exposed to the hydrophilic pore to one that is so exposed in the open state. The results further show that M314 might not actually form the part of the activation gate that blocks ion passage, but that motions in the deep pore may be required for blocking ion passage elsewhere in the channel.

The findings point to new directions for research regarding the molecular mechanisms of BK channel activation, according to Commentary by Daniel Cox (Tufts University School of Medicine) and Toshinori Hoshi (University of Pennsylvania). Importantly, they say, the study demonstrates that BK channel activation is not an open-and-shut case as previously suspected.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal References:

  1. D. H. Cox, T. Hoshi. Where's the gate? Gating in the deep pore of the BKCa channel. The Journal of General Physiology, 2011; DOI: 10.1085/jgp.201110681
  2. X. Chen, R. W. Aldrich. Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating. The Journal of General Physiology, 2011; DOI: 10.1085/jgp.201110632

Cite This Page:

Rockefeller University Press. "New clues to the structural dynamics of BK channels." ScienceDaily. ScienceDaily, 14 July 2011. <www.sciencedaily.com/releases/2011/07/110714120720.htm>.
Rockefeller University Press. (2011, July 14). New clues to the structural dynamics of BK channels. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2011/07/110714120720.htm
Rockefeller University Press. "New clues to the structural dynamics of BK channels." ScienceDaily. www.sciencedaily.com/releases/2011/07/110714120720.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pygmy Marmoset Getting a Toothbrush Massage Is the Cutest

Pygmy Marmoset Getting a Toothbrush Massage Is the Cutest

Buzz60 (Nov. 19, 2014) This rescued pygmy marmoset named Ninita is obsessed with her toothbrush. It's cuteness overload, and Sean Dowling (@SeanDowlingTV) has the amazing video. Video provided by Buzz60
Powered by NewsLook.com
Why Are Chocolate Makers So Worried?

Why Are Chocolate Makers So Worried?

Reuters - Business Video Online (Nov. 19, 2014) Two big chocolate producers are warning the popular treat could run out by 2020 because people are eating it faster than farmers can grow cocoa. Ciara Lee reports Video provided by Reuters
Powered by NewsLook.com
Tiny Hamster Eating Thanksgiving Meal Breaks the Internet

Tiny Hamster Eating Thanksgiving Meal Breaks the Internet

Buzz60 (Nov. 19, 2014) A tiny hamster and a bunny and rat enjoy a tiny Thanksgiving meal where they stuff themselves to the brim. Sean Dowling (@SeanDowlingTV) has the cute video. Video provided by Buzz60
Powered by NewsLook.com
Giant Panda at Toronto Zoo Loves Somersaulting in the Snow

Giant Panda at Toronto Zoo Loves Somersaulting in the Snow

Buzz60 (Nov. 19, 2014) A giant panda at the Toronto Zoo named Da Mao is celebrating the northeast snowfall by playing and tumbling in the snow in his outdoor enclosure. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins