Featured Research

from universities, journals, and other organizations

Compound to block signaling of cancer-causing protein developed

Date:
July 17, 2011
Source:
New York University
Summary:
Researchers have developed a compound that blocks signaling from a protein implicated in many types of cancer.

Researchers at New York University's Department of Chemistry and NYU Langone Medical Center have developed a compound that blocks signaling from a protein implicated in many types of cancer. The compound is described in the latest issue of the journal Nature Chemical Biology.

Related Articles


The researchers examined signaling by receptor tyrosine kinase (RTK). Abnormal RTK signaling is a major underlying cause of various developmental disorders and diseases, including many forms of cancer. RTK signaling pathway employs interactions between proteins Sos and Ras, and accounts for a broad range of molecular changes that underlie various cancers and other diseases. Disrupting the Sos-Ras interaction, then, is crucial to stemming the production of cancer cells.

However, interactions between large protein molecules such as Ras and Sos have been difficult to modulate with artificial means. Through a series of experimental and computational analyses, the scientists hypothesized that by mimicking a key portion of Sos, they might disrupt its interactions with Ras. Specifically, they observed that Sos activates Ras through a helix -- a critical portion of Sos that makes contact with Ras. Creation of this Sos mimetic required a method for locking correct helical shapes in synthetic strings of amino acids -- a method previously developed at NYU School of Medicine.

The researchers note that synthetic Sos may offer a lead for the creation of pharmaceuticals that can block Sos-Ras interaction.

The study was co-authored by Paramjit Arora, associate professor in the Department of Chemistry, Anupam Patgiri, graduate student in the Department of Chemistry, Dafna Bar-Sagi, professor in the Department of Biochemistry, and Kamlesh Yadav, graduate student in the Department of Biochemistry.

The research was supported by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Anupam Patgiri, Kamlesh K Yadav, Paramjit S Arora, Dafna Bar-Sagi. An orthosteric inhibitor of the Ras-Sos interaction. Nature Chemical Biology, 2011; DOI: 10.1038/nchembio.612

Cite This Page:

New York University. "Compound to block signaling of cancer-causing protein developed." ScienceDaily. ScienceDaily, 17 July 2011. <www.sciencedaily.com/releases/2011/07/110717134811.htm>.
New York University. (2011, July 17). Compound to block signaling of cancer-causing protein developed. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/07/110717134811.htm
New York University. "Compound to block signaling of cancer-causing protein developed." ScienceDaily. www.sciencedaily.com/releases/2011/07/110717134811.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins