Featured Research

from universities, journals, and other organizations

Obesity accelerates progression of cirrhosis, study suggests

Date:
July 22, 2011
Source:
Wiley-Blackwell
Summary:
Researchers have determined that increased body mass index (BMI) is an independent predictor of clinical decompensation in patients with compensated cirrhosis, independent of portal pressure and liver function.

Researchers from the United States and Europe involved in an NIH-funded multicenter study have determined that increased body mass index (BMI) is an independent predictor of clinical decompensation in patients with compensated cirrhosis, independent of portal pressure and liver function. The findings suggest obesity accelerates cirrhosis progression and measures to reduce BMI could improve the prognosis for patients with advanced liver disease.

Related Articles


Study details are available in the August issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

Obesity is a global health epidemic and according to a 2008 report by the World Health Organization (WHO), 1.5 billion adults, age 20 and older, were overweight and worldwide obesity more than doubled since 1980. Of those in the overweight population, WHO estimates more than 200 million men and close to 300 million women were obese. Prior studies have shown that obesity is a frequent cause of chronic liver disease that can progress to cirrhosis, and one study estimated that 17% of liver cirrhosis is attributable to excess body weight. Further studies found lower survival rates among patients with cirrhosis caused by obesity-related liver disease than from viral cirrhosis.

"Given the prior evidence of the detrimental effects of obesity on chronic liver disease, we hypothesized that increased BMI may increase the risk of transition from compensated to decompensated cirrhosis," said Dr. Guadalupe Garcia-Tsao, Professor of Medicine at Yale University School of Medicine in Connecticut. The research team recruited 161 patients with compensated cirrhosis from a trial of betablockers used for varices prevention. Participants were followed until clinical decompensation (ascites, hepatic encephalopathy or variceal hemorrhage) occurred, or until September 2002. Laboratory tests and portal pressure, assessed by the hepatic venous pressure gradient, were performed.

BMI analysis showed that 29% of participants were in normal range, 40% were overweight and 30% were obese. Study subjects were followed for a median of 59 months, with clinical decompensation occurring in 30% of patients. Decompensation of cirrhosis (that is, development of ascites, variceal hemorrhage or hepatic encephalopathy) was observed at higher rates in patients at the upper end of BMI -- 31% of overweight and 43% of obese patients -- compared to only 15% of patients with normal BMI. Researchers noted the probability of developing clinical decompensation was significantly higher in patients with abnormal BMI.

"Patients who are overweight or obese are at greater risk of accelerating the progression of cirrhosis," concluded Dr. Garcia-Tsao. "Weight reduction may improve patient outcomes in this high-risk population and studies addressing this specific issue are warranted."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Annalisa Berzigotti, Guadalupe Garcia-Tsao, Jaime Bosch, Norman D. Grace, Andrew K. Burroughs, Rosa Morillas, Angels Escorsell, Juan Carlos Garcia-Pagan, David Patch, Daniel S. Matloff, Roberto J. Groszmann. Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis. Hepatology, 2011; DOI: 10.1002/hep.24418

Cite This Page:

Wiley-Blackwell. "Obesity accelerates progression of cirrhosis, study suggests." ScienceDaily. ScienceDaily, 22 July 2011. <www.sciencedaily.com/releases/2011/07/110721101503.htm>.
Wiley-Blackwell. (2011, July 22). Obesity accelerates progression of cirrhosis, study suggests. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2011/07/110721101503.htm
Wiley-Blackwell. "Obesity accelerates progression of cirrhosis, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/07/110721101503.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins