Featured Research

from universities, journals, and other organizations

Researchers help find natural products potential of frankia bacteria

Date:
August 2, 2011
Source:
University of New Hampshire
Summary:
Soil-dwelling bacteria of the genus Frankia have the potential to produce a multitude of natural products, including antibiotics, herbicides, pigments, anticancer agents, and other useful products, according to a new article.

Soil-dwelling bacteria of the genus Frankia have the potential to produce a multitude of natural products, including antibiotics, herbicides, pigments, anticancer agents, and other useful products, according to an article in the June 2011 issue of the journal Applied and Environmental Microbiology. University of New Hampshire professor of microbiology and genetics Louis Tisa, a Frankia expert, contributed the genomic analysis to this study.

Related Articles


"We were able to use cutting-edge techniques to identify unexpected compounds in this organism, Frankia," Tisa says. The researchers, led by Bradley Moore of the Scripps Oceanographic Institute, found genetic structures in Frankia that resemble those of various valuable natural product categories that produce the majority of the natural antibiotics used as drugs.

Frankia are nitrogen-fixing bacteria that live in symbiosis with actinorhizal plants (whose ranks include beech and cherry trees); they have not previously been exploited partly because these bacteria are difficult to grow in the lab. But new genetic methods make it easier to transplant genes for promising natural products from Frankia into more user-friendly host bacteria for production.

"We found something unique that nobody thought to look for in these bacteria," says Tisa, who worked with his former graduate student and current lab technician Nicholas Beauchemin, on the project.

Tisa's lab provided insight on the biology that contributed to the genome mining, a recent technique that involves searching for genetic sequences, that was critical to the results and "complementary to the far more laborious traditional natural product drug discovery that has gone unchanged for decades," Moore says.

The project grew out of a graduate class that Moore and co-author Daniel Udwary (then his post-doc, now at the University of Rhode Island) taught on "Microbial Genome Mining." The students -- who are the majority of coauthors on the paper -- annotated their genes and based on biosynthetic principles, and predicted pathways leading to putative natural products. They then worked with the laboratories of Pieter Dorrestein at the University of California, San Diego, and Tisa to conduct preliminary proteomic and metabolomic analyses to probe whether the predicted pathways were operative, and whether small molecule chemistry was evident.


Story Source:

The above story is based on materials provided by University of New Hampshire. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. W. Udwary, E. A. Gontang, A. C. Jones, C. S. Jones, A. W. Schultz, J. M. Winter, J. Y. Yang, N. Beauchemin, T. L. Capson, B. R. Clark, E. Esquenazi, A. S. Eustaquio, K. Freel, L. Gerwick, W. H. Gerwick, D. Gonzalez, W.-T. Liu, K. L. Malloy, K. N. Maloney, M. Nett, J. K. Nunnery, K. Penn, A. Prieto-Davo, T. L. Simmons, S. Weitz, M. C. Wilson, L. S. Tisa, P. C. Dorrestein, B. S. Moore. Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses. Applied and Environmental Microbiology, 2011; 77 (11): 3617 DOI: 10.1128/AEM.00038-11

Cite This Page:

University of New Hampshire. "Researchers help find natural products potential of frankia bacteria." ScienceDaily. ScienceDaily, 2 August 2011. <www.sciencedaily.com/releases/2011/08/110802163935.htm>.
University of New Hampshire. (2011, August 2). Researchers help find natural products potential of frankia bacteria. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2011/08/110802163935.htm
University of New Hampshire. "Researchers help find natural products potential of frankia bacteria." ScienceDaily. www.sciencedaily.com/releases/2011/08/110802163935.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com
Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins