Featured Research

from universities, journals, and other organizations

New insights into the how the powerhouse of the cell works

Date:
August 10, 2011
Source:
Universitaet Tübingen
Summary:
Mitochondria are the powerhouse of the cell. They are thought to have evolved more than a billion years ago from primitive bacterium which was engulfed by an early eukaryotic cell resulting in endosymbiotic relationships between the host cell and the newly formed organelle. During evolution the vast majority of the mitochondrial genetic material left the organelle and got integrated into the nucleus of the host cell. Hence, most of the mitochondrial proteins are synthesized outside of the organelle and have to be imported into the various internal mitochondrial compartments.

Mitochondria are the powerhouse of the cell. They are thought to have evolved more than a billion years ago from primitive bacterium which was engulfed by an early eukaryotic cell resulting in endosymbiotic relationships between the host cell and the newly formed organelle. During evolution the vast majority of the mitochondrial genetic material left the organelle and got integrated into the nucleus of the host cell. Hence, most of the mitochondrial proteins are synthesized outside of the organelle and have to be imported into the various internal mitochondrial compartments.

Researchers from the Interfaculty Institute of Biochemistry (IFIB) of the University of Tübingen characterized recently a novel import pathway into the mitochondria. The group of Doron Rapaport employs a wide variety of genetic, biochemical and molecular cell biology methods in their studies. In the current project they used radiolabeled proteins and mitochondria isolated from yeast cells. Using this approach they discovered an unknown import route that is taken by a sub-group of proteins that span the mitochondrial outer membrane with multiple domains. The group could identify the components involved in this import pathway and to characterize their contribution to the process.

These findings are reported in the current issue of the Journal of Cell Biology.

This work contributes to our understanding of the formation of the organelle and its maintenance within the cell. As mitochondrial defects are playing an important role in many human sicknesses, these findings can add to our perception of these diseases.


Story Source:

The above story is based on materials provided by Universitaet Tübingen. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Papic, K. Krumpe, J. Dukanovic, K. S. Dimmer, D. Rapaport. Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. The Journal of Cell Biology, 2011; 194 (3): 397 DOI: 10.1083/jcb.201102041

Cite This Page:

Universitaet Tübingen. "New insights into the how the powerhouse of the cell works." ScienceDaily. ScienceDaily, 10 August 2011. <www.sciencedaily.com/releases/2011/08/110809083240.htm>.
Universitaet Tübingen. (2011, August 10). New insights into the how the powerhouse of the cell works. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2011/08/110809083240.htm
Universitaet Tübingen. "New insights into the how the powerhouse of the cell works." ScienceDaily. www.sciencedaily.com/releases/2011/08/110809083240.htm (accessed April 23, 2014).

Share This



More Plants & Animals News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Monkeys Are Better At Math Than We Thought, Study Shows

Monkeys Are Better At Math Than We Thought, Study Shows

Newsy (Apr. 23, 2014) — A Harvard University study suggests monkeys can use symbols to perform basic math calculations. Video provided by Newsy
Powered by NewsLook.com
Raw: Leopard Bites Man in India

Raw: Leopard Bites Man in India

AP (Apr. 22, 2014) — A leopard caused panic in the city of Chandrapur on Monday when it sprung from the roof of a house and charged at rescue workers. (April 22) Video provided by AP
Powered by NewsLook.com
Iowa College Finds Beauty in Bulldogs

Iowa College Finds Beauty in Bulldogs

AP (Apr. 22, 2014) — Drake University hosts 35th annual Beautiful Bulldog Contest. (April 21) Video provided by AP
Powered by NewsLook.com
805-Pound Shark Caught Off The Coast Of Florida

805-Pound Shark Caught Off The Coast Of Florida

Newsy (Apr. 22, 2014) — One Florida fisherman caught a 805-pound shark off the coast of Florida earlier this month. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins