Featured Research

from universities, journals, and other organizations

New insights into the how the powerhouse of the cell works

Date:
August 10, 2011
Source:
Universitaet Tübingen
Summary:
Mitochondria are the powerhouse of the cell. They are thought to have evolved more than a billion years ago from primitive bacterium which was engulfed by an early eukaryotic cell resulting in endosymbiotic relationships between the host cell and the newly formed organelle. During evolution the vast majority of the mitochondrial genetic material left the organelle and got integrated into the nucleus of the host cell. Hence, most of the mitochondrial proteins are synthesized outside of the organelle and have to be imported into the various internal mitochondrial compartments.

Mitochondria are the powerhouse of the cell. They are thought to have evolved more than a billion years ago from primitive bacterium which was engulfed by an early eukaryotic cell resulting in endosymbiotic relationships between the host cell and the newly formed organelle. During evolution the vast majority of the mitochondrial genetic material left the organelle and got integrated into the nucleus of the host cell. Hence, most of the mitochondrial proteins are synthesized outside of the organelle and have to be imported into the various internal mitochondrial compartments.

Related Articles


Researchers from the Interfaculty Institute of Biochemistry (IFIB) of the University of Tübingen characterized recently a novel import pathway into the mitochondria. The group of Doron Rapaport employs a wide variety of genetic, biochemical and molecular cell biology methods in their studies. In the current project they used radiolabeled proteins and mitochondria isolated from yeast cells. Using this approach they discovered an unknown import route that is taken by a sub-group of proteins that span the mitochondrial outer membrane with multiple domains. The group could identify the components involved in this import pathway and to characterize their contribution to the process.

These findings are reported in the current issue of the Journal of Cell Biology.

This work contributes to our understanding of the formation of the organelle and its maintenance within the cell. As mitochondrial defects are playing an important role in many human sicknesses, these findings can add to our perception of these diseases.


Story Source:

The above story is based on materials provided by Universitaet Tübingen. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Papic, K. Krumpe, J. Dukanovic, K. S. Dimmer, D. Rapaport. Multispan mitochondrial outer membrane protein Ugo1 follows a unique Mim1-dependent import pathway. The Journal of Cell Biology, 2011; 194 (3): 397 DOI: 10.1083/jcb.201102041

Cite This Page:

Universitaet Tübingen. "New insights into the how the powerhouse of the cell works." ScienceDaily. ScienceDaily, 10 August 2011. <www.sciencedaily.com/releases/2011/08/110809083240.htm>.
Universitaet Tübingen. (2011, August 10). New insights into the how the powerhouse of the cell works. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2011/08/110809083240.htm
Universitaet Tübingen. "New insights into the how the powerhouse of the cell works." ScienceDaily. www.sciencedaily.com/releases/2011/08/110809083240.htm (accessed October 31, 2014).

Share This



More Plants & Animals News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Watch Baby Goose Survive A 400-Foot Cliff Dive

Watch Baby Goose Survive A 400-Foot Cliff Dive

Buzz60 (Oct. 31, 2014) — For its nature series Life Story, the BBC profiled the barnacle goose, whose chicks must make a daredevil 400-foot cliff dive from their nests to find food. Jen Markham has the astonishing video. Video provided by Buzz60
Powered by NewsLook.com
World's Salamanders At Risk From Flesh-Eating Fungus

World's Salamanders At Risk From Flesh-Eating Fungus

Newsy (Oct. 31, 2014) — The import of salamanders around the globe is thought to be contributing to the spread of a deadly fungus. Video provided by Newsy
Powered by NewsLook.com
Alcoholic Drinks In The E.U. Could Get Calorie Labels

Alcoholic Drinks In The E.U. Could Get Calorie Labels

Newsy (Oct. 31, 2014) — A health group in the United Kingdom has called for mandatory calorie labels on alcoholic beverages in the European Union. Video provided by Newsy
Powered by NewsLook.com
Malaria Threat in Liberia as Fight Against Ebola Rages

Malaria Threat in Liberia as Fight Against Ebola Rages

AFP (Oct. 31, 2014) — Focus on treating the Ebola epidemic in Liberia means that treatment for malaria, itself a killer, is hard to come by. MSF are now undertaking the mass distribution of antimalarials in Monrovia. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins