Featured Research

from universities, journals, and other organizations

Six new genetic variants linked to type 2 diabetes discovered in South Asians

Date:
August 30, 2011
Source:
Imperial College London
Summary:
Scientists have identified six new genetic variants associated with type 2 diabetes in South Asians.

An international team of researchers led by Imperial College London has identified six new genetic variants associated with type 2 diabetes in South Asians. The findings, published in Nature Genetics, give scientists new leads in the search for diagnostic markers and drug targets to prevent and treat this major disease.

People of South Asian ancestry are up to four times more likely than Europeans to develop type 2 diabetes, which is a major risk factor for heart disease and stroke. Around 55 million South Asian people are affected worldwide, and the number is projected to rise to 80 million by 2030.

This new study is the first to focus on genes underlying diabetes amongst people originating from South Asia (India, Pakistan, Sri Lanka and Bangladesh). The researchers from around the world examined the DNA of 18,731 people with type 2 diabetes and 39,856 healthy controls. The genomes of the participants were analysed to look for locations where variations were more common in those with diabetes. The results identified six positions where differences of a single letter in the genetic code were associated with type 2 diabetes, suggesting that nearby genes have a role in the disease.

Dr John Chambers, the senior author of the study, from the School of Public Health at Imperial College London, said: "Type 2 diabetes is more common in South Asian populations than any other ethnic group, but the reason for this increased risk is unclear. Although lifestyle factors such as unhealthy diet, physical inactivity and obesity are important causes of diabetes in South Asians, these are only part of the explanation. Genetic factors have been widely considered to play a role in the increased risk of type 2 diabetes in Asians, but to date have not been systematically explored in this population."

"Our study identifies six new genetic variants linked to type 2 diabetes in South Asians. Our findings give important new insight into the genes underlying of diabetes in this population, which in the long term might lead to new treatments to prevent diabetes."

Professor Jaspal S Kooner, from the National Heart and Lung Institute at Imperial College London, the lead author for the study said: "This is the first genome-wide association study in South Asians, who comprise one-quarter of the globe's population, and who carry a high burden of the disease and its complications, including heart attack and stroke. We have shown that the genetic variants discovered here in South Asians also exist and contribute to diabetes in Europeans. Our studies in Asians and European populations highlight the importance and gain in examining the same problem in different ethnic groups."

The collaboration included leading researchers from Imperial College London, University of Oxford, University of Cambridge, the University of Birmingham, and the Peninsular Medical School in the UK, as well National University of Singapore, University of Mauritius, Baker IDI (Australia), Mohan Diabetes Centre (India), University of Kelaniya (Sri Lanka), NCGM (Japan), University of Houston (USA), Aga Khan University (Pakistan) and other institutions.

The research was funded by the Imperial Comprehensive Biomedical Research Centre award from the National Institute of Health Research; the Medical Research Council, the Wellcome Trust and other sources.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jaspal S Kooner, Danish Saleheen, Xueling Sim, Joban Sehmi, Weihua Zhang, Philippe Frossard, Latonya F Been, Kee-Seng Chia, Antigone S Dimas, Neelam Hassanali, Tazeen Jafar, Jeremy B M Jowett, Xinzhing Li, Venkatesan Radha, Simon D Rees, Fumihiko Takeuchi, Robin Young, Tin Aung, Abdul Basit, Manickam Chidambaram, Debashish Das, Elin Grunberg, Åsa K Hedman, Zafar I Hydrie, Muhammed Islam, Chiea-Chuen Khor, Sudhir Kowlessur, Malene M Kristensen, Samuel Liju, Wei-Yen Lim, David R Matthews, Jianjun Liu, Andrew P Morris, Alexandra C Nica, Janani M Pinidiyapathirage, Inga Prokopenko, Asif Rasheed, Maria Samuel, Nabi Shah, A Samad Shera, Kerrin S Small, Chen Suo, Ananda R Wickremasinghe, Tien Yin Wong, Mingyu Yang, Fan Zhang, Goncalo R Abecasis, Anthony H Barnett, Mark Caulfield, Panos Deloukas, Timothy M Frayling, Philippe Froguel, Norihiro Kato, Prasad Katulanda, M Ann Kelly, Junbin Liang, Viswanathan Mohan, Dharambir K Sanghera, James Scott, Mark Seielstad, Paul Z Zimmet, Paul Elliott, Yik Ying Teo, Mark I McCarthy, John Danesh, E Shyong Tai, John C Chambers. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genetics, 2011; DOI: 10.1038/ng.921

Cite This Page:

Imperial College London. "Six new genetic variants linked to type 2 diabetes discovered in South Asians." ScienceDaily. ScienceDaily, 30 August 2011. <www.sciencedaily.com/releases/2011/08/110828140935.htm>.
Imperial College London. (2011, August 30). Six new genetic variants linked to type 2 diabetes discovered in South Asians. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2011/08/110828140935.htm
Imperial College London. "Six new genetic variants linked to type 2 diabetes discovered in South Asians." ScienceDaily. www.sciencedaily.com/releases/2011/08/110828140935.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins