Featured Research

from universities, journals, and other organizations

New insight into immune tolerance furthers understanding of autoimmune disease

Date:
September 21, 2011
Source:
Cell Press
Summary:
The mechanisms that underlie immune activation and tolerance are not completely understood. Now, a new research study provides intriguing insight into the complex immune regulatory mechanisms that underlie immune tolerance.

A sample from a normal lung is on the left, and from a diseased lung on the right. Immune cells invade lung tissue when GATA-3 is absent in Tregs.
Credit: Wan Lab, UNC Lineberger Comprehensive Cancer Center.

It is no easy task to preserve the delicate balance that allows us to maintain a strong immune system that can defend us from harmful pathogens, but that is sensitive enough to correctly identify and spare our own cells. Therefore, it is not surprising that the mechanisms that underlie immune activation and tolerance are not completely understood. Now, a new research study published by Cell Press in the journal Immunity and available online on Sept. 15 provides intriguing insight into the complex immune regulatory mechanisms that underlie immune tolerance.

Cells called Foxp3-expressing regulatory T cells, or "Treg cells," are a subpopulation of immune cells that suppress the immune system to maintain self tolerance. These regulatory "suppressor" cells have to recognize our own cells as "self" in order to turn off the effector arm of the immune system so that it does not attack our own healthy tissues and cause an autoimmune or inflammatory disease. There has been a lot of interest in Treg cells because it has been hypothesized that these cells might be useful for treating autoimmune disease or facilitating organ transplantation. "Foxp3 is a transcription factor that is important for Treg cell function," explains senior study author, Dr. Yisong Y. Wan, from the University of North Carolina at Chapel Hill. "If we are going to fully understand immune tolerance and regulation, it is critical to understand how Treg and Foxp3 function are controlled."

Dr. Wan and colleagues were interested looking at a second transcription factor, GATA-3, best known as a master regulator of another type of immune cell. "GATA-3 plays multi-faceted roles of regulating immune function in a cell-type specific fashion," says Dr. Wan. "However, whether and how GATA-3 is involved in controlling Treg function was unknown." The researchers discovered that when GATA-3 was deleted from Treg cells, mice developed a spontaneous inflammatory disorder and that Treg cells were defective in their ability to suppress the immune system. They went on to show that GATA-3 controls Foxp3 expression by binding to a regulatory region in the Foxp3 gene and that defects in both GATA-3 and Foxp3 resulted in substantially impaired Treg cells.

Therefore, the investigators have shown that one transcription factor (GATA-3) can control the expression of another transcription factor (FoxP3) to drive functional differentiation of Treg cells. By evolutionarily engineering a multi-layered process of transcriptional regulation, nature has provided for the opportunity to finely tune the generation of Treg cells. "Our study provides novel insights into the modulation of Treg function, revealing an indispensible role of GATA-3 in regulating Treg function and immune tolerance," concludes Dr. Wan. "We suggest that GATA-3 expression in Treg cells is important for the modulation of Treg function and immune response, and thus needs to be considered in order to fully understand how protective (to clear pathogen) and pathogenic (to cause autoimmunity and inflammatory disease) immune responses are controlled."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yunqi Wang, Maureen A. Su, Yisong Y. Wan. An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells. Immunity, 2011; DOI: 10.1016/j.immuni.2011.08.012

Cite This Page:

Cell Press. "New insight into immune tolerance furthers understanding of autoimmune disease." ScienceDaily. ScienceDaily, 21 September 2011. <www.sciencedaily.com/releases/2011/09/110915134406.htm>.
Cell Press. (2011, September 21). New insight into immune tolerance furthers understanding of autoimmune disease. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2011/09/110915134406.htm
Cell Press. "New insight into immune tolerance furthers understanding of autoimmune disease." ScienceDaily. www.sciencedaily.com/releases/2011/09/110915134406.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Newsy (Oct. 2, 2014) Coverage of the lone Ebola patient discovered in Texas has U.S. media in a frenzy — but does the coverage match the reality? Video provided by Newsy
Powered by NewsLook.com
Rhode Island Child With Enterovirus Dies After Infection

Rhode Island Child With Enterovirus Dies After Infection

Reuters - US Online Video (Oct. 2, 2014) A Rhode Island child hospitalized with Enterovirus D68 has died of a bacterial infection, in what state public health officials say was an unusual and dangerous combination. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
US Hunts Contacts of Ebola Patient, Including Children

US Hunts Contacts of Ebola Patient, Including Children

AFP (Oct. 2, 2014) Health officials in Texas on Wednesday scoured the Dallas area for people, including schoolchildren, who came in contact with a Liberian man who was diagnosed with Ebola in the United States. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Study Says Losing Sense Of Smell Can Indicate Death

Study Says Losing Sense Of Smell Can Indicate Death

Newsy (Oct. 2, 2014) Researchers found elderly adults with a poor sense of smell are more likely to die within five years. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Components That Keep Immune System in Check Identified

Sep. 19, 2011 Researchers have revealed the genetic underpinnings of cells -- called Foxp3-expressing regulatory T cells or Tregs -- that can prevent the immune response from turning cannibalistic. Their finding ... read more

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins