Featured Research

from universities, journals, and other organizations

HIV: Ancient gene found to control potent antibody response to retroviruses

Date:
October 9, 2011
Source:
Public Library of Science
Summary:
A researcher has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses. He has shown that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction.

A researcher at MIT's Koch Institute for Integrative Cancer research has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses. Edward Browne shows that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction. The findings are published in the Open Access journal PLoS Pathogens on October 6th.

Related Articles


TLR7 is a member of an ancient family of genes whose distant ancestors can also be found as far back as insects and worms, but these results show that the immune system has co-opted these genes for a new purpose -- the generation of antibodies.

Antibodies are a key feature of our ability to fight off disease causing viruses, but for some viruses such as HIV, this response goes horribly wrong. People infected with HIV generate large amounts of apparently useless antibodies that lack to power to hurt the virus. Why this happens during HIV infection, and how to fix the problem is one of the biggest challenges facing researchers in the HIV field.

During the germinal center reaction, antibodies become mutated and undergo selection to allow the strongest antibodies to dominate. Dr. Browne notes that "these results identify TLR7 as an important gene that could be targeted to improve antibody responses in HIV patients. It's possible that in HIV patients this process could be enhanced or accelerated to speed up the formation of high affinity broadly neutralizing antibodies."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Edward P. Browne. Toll-like Receptor 7 Controls the Anti-Retroviral Germinal Center Response. PLoS Pathogens, 2011; 7 (10): e1002293 DOI: 10.1371/journal.ppat.1002293

Cite This Page:

Public Library of Science. "HIV: Ancient gene found to control potent antibody response to retroviruses." ScienceDaily. ScienceDaily, 9 October 2011. <www.sciencedaily.com/releases/2011/10/111006173445.htm>.
Public Library of Science. (2011, October 9). HIV: Ancient gene found to control potent antibody response to retroviruses. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2011/10/111006173445.htm
Public Library of Science. "HIV: Ancient gene found to control potent antibody response to retroviruses." ScienceDaily. www.sciencedaily.com/releases/2011/10/111006173445.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins