Featured Research

from universities, journals, and other organizations

Circadian rhythms have profound influence on metabolic output

Date:
March 19, 2012
Source:
University of California - Irvine
Summary:
By analyzing the hundreds of metabolic products present in the liver, researchers have discovered that circadian rhythms -- our own body clock -- greatly control the production of such key building blocks as amino acids, carbohydrates and lipids.

By analyzing the hundreds of metabolic products present in the liver, researchers with the UC Irvine Center for Epigenetics & Metabolism have discovered that circadian rhythms -- our own body clock -- greatly control the production of such key building blocks as amino acids, carbohydrates and lipids.

They identified more than 600 liver-originated metabolites, which are the chemical substances created by metabolism that sustain and promote cell health and growth. Approximately 60 percent of these metabolites were found to be dependent on the endogenous circadian clock -- many more than expected, as only about 15 percent of the body's genes are regulated by it.

Circadian rhythms over 24 hours govern fundamental biological and physiological processes in almost all organisms. They anticipate environmental changes and adapt certain bodily functions to the appropriate time of day. Disruption of these cycles can seriously affect human health.

Center for Epigenetics & Metabolism director Paolo Sassone-Corsi, lead author on the study and one of the world's preeminent researchers on circadian rhythms, said the liver metabolites reveal how the body clock -- through the main circadian gene, CLOCK -- orchestrates the interplay between metabolites and signaling proteins in much the same way a conductor leads a symphony.

"Metabolites and signaling proteins -- like the horns and strings in an orchestra -- need to be perfectly coordinated, and we've found that CLOCK provides that direction," he said.

Since external cues such as day-night lighting patterns and nutrition influence the circadian machinery, metabolites and their relationship to signaling proteins in cells seem to be acutely tied to circadian disruptions. This may help explain, Sassone-Corsi added, some of the primary physiological factors underlying obesity, high cholesterol and metabolic-based diseases like diabetes.

"This interplay has far-reaching implications for human illness and aging, and it is likely vital for proper metabolism," he said. Study results appear this week in the early online edition of the Proceedings of the National Academy of Sciences.

"By identifying the relationship between metabolites and the body clock, we have taken a first step toward a better understanding of how nutrients interact with our metabolism, giving researchers a new opportunity to spot the optimal times for us to get the fullest benefits from the foods we eat and the medications we take," added Kristin Eckel-Mahan, a UCI postdoctoral researcher in biological chemistry and study co-author.

Working with Metabolon Inc., Sassone-Corsi and Eckel-Mahan created the first liver metabolome -- the full set of metabolites. With this information, they partnered with Pierre Baldi, director of UCI's Institute for Genomics & Bioinformatics, and his graduate student Vishal Patel to analyze the data and build CircadiOmics, a Web-based data system that provides detailed profiles of the metabolites and related genes in the liver and the underlying networks through which they interact.

"Within CircadiOmics, we were able to integrate this circadian metabolite data with multiple other data sources to generate the first comprehensive map of the liver metabolome and its circadian oscillations and develop regulatory hypotheses that have been confirmed in the laboratory," said Baldi, Chancellor's Professor of computer science. "CircadiOmics is being expanded with metabolic data about other tissues and conditions and will be invaluable to further our understanding of the interplay between metabolism and circadian rhythms in healthy and diseased states."

Robert Mohney and Katie Vignola of Metabolon, in Durham, N.C., contributed to the study, which received National Institutes of Health and National Science Foundation support.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kristin L. Eckel-Mahan, Vishal R. Patel, Robert P. Mohney, Katie S. Vignola, Pierre Baldi, and Paolo Sassone-Corsi. Coordination of the transcriptome and metabolome by the circadian clock. PNAS, March 19, 2012 DOI: 10.1073/pnas.1118726109

Cite This Page:

University of California - Irvine. "Circadian rhythms have profound influence on metabolic output." ScienceDaily. ScienceDaily, 19 March 2012. <www.sciencedaily.com/releases/2012/03/120319163803.htm>.
University of California - Irvine. (2012, March 19). Circadian rhythms have profound influence on metabolic output. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2012/03/120319163803.htm
University of California - Irvine. "Circadian rhythms have profound influence on metabolic output." ScienceDaily. www.sciencedaily.com/releases/2012/03/120319163803.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins