Featured Research

from universities, journals, and other organizations

Possible connection between air pollution and tuberculosis susceptibility

Date:
April 13, 2012
Source:
University of Medicine and Dentistry of New Jersey (UMDNJ)
Summary:
Researchers have determined a possible link between exposure to a component of urban air pollution and a change in the function of immune cells that protect against the bacteria that cause tuberculosis.

A team of researchers, led by Dr. Stephan Schwander, of the University of Medicine and Dentistry of New Jersey -- School of Public Health (UMDNJ-SPH), has determined a possible link between exposure to a common component of urban air pollution and a change in the function of important immune cells that protect against the bacteria that cause tuberculosis (Mycobacterium tuberculosis). Writing in the Journal of Immunology, the scientists describe their findings that exposure to diesel exhaust particles (DEP) suppresses the function of phagocytic immune cells (a type of white blood cells that ingest foreign particles, such as bacteria) on a cellular level.

They conclude that this exposure probably causes exposed individuals to be less able to fight off new Mycobacterium tuberculosis infections or to suppress a reactivation of a latent infection by these bacteria.

"In laboratory experiments using DEP generated from an automobile diesel engine as model air pollutant particles, and blood samples gathered from 20 healthy individuals, we demonstrated that exposure to DEP makes cells less responsive," said Schwander. "The cells, in effect, became desensitized to stimulation with the bacteria that cause TB," he explained. "This effect was even greater in cells that had prior exposure to DEP than in those that had concurrent DEP and Mycobacterium tuberculosis exposure."

Tuberculosis is estimated to afflict approximately 8-10 million people and to cause 1.5 million deaths each year worldwide. The incidence of the disease is particularly high in low- and middle-income countries that are experiencing rapid industrial growth and increases in motor vehicle traffic in densely populated urban areas. By the year 2030, scientists estimate that 50 percent of the world's population will live in urban environments.

"Because there is already epidemiological evidence that connects tuberculosis to cigarette smoking and some forms of indoor air pollution, it seemed logical to look at outdoor air pollution for a similar correlation," Schwander added. "The models we used indicated that this may, in fact, be the case. The next step is to see if these results can be confirmed by larger epidemiological studies, conducted in a real world environment."


Story Source:

The above story is based on materials provided by University of Medicine and Dentistry of New Jersey (UMDNJ). Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Sarkar, Y. Song, S. Sarkar, H. M. Kipen, R. J. Laumbach, J. Zhang, P. A. Ohman Strickland, C. R. Gardner, S. Schwander. Suppression of the NF-B Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity. The Journal of Immunology, 2012; 188 (6): 2778 DOI: 10.4049/jimmunol.1101380

Cite This Page:

University of Medicine and Dentistry of New Jersey (UMDNJ). "Possible connection between air pollution and tuberculosis susceptibility." ScienceDaily. ScienceDaily, 13 April 2012. <www.sciencedaily.com/releases/2012/04/120413162343.htm>.
University of Medicine and Dentistry of New Jersey (UMDNJ). (2012, April 13). Possible connection between air pollution and tuberculosis susceptibility. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2012/04/120413162343.htm
University of Medicine and Dentistry of New Jersey (UMDNJ). "Possible connection between air pollution and tuberculosis susceptibility." ScienceDaily. www.sciencedaily.com/releases/2012/04/120413162343.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins