Featured Research

from universities, journals, and other organizations

Fat outside of arteries may influence onset of coronary artery disease

Date:
April 20, 2012
Source:
University of Cincinnati Academic Health Center
Summary:
Researchers have confirmed that fat surrounding the outside of arteries in humans -- particularly the left coronary artery -- may influence the onset of coronary artery disease, or atherosclerosis, which is the leading cause of death in the US.

Researchers at UC have confirmed that fat surrounding the outside of arteries in humans -- particularly the left coronary artery -- may influence the onset of coronary artery disease, or atherosclerosis, which is the leading cause of death in the U.S.

These findings, being presented at the American Heart Association's Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) 2012 Scientific Sessions in Chicago April 20, 2012, may help in identifying the molecular culprit, with the goal of creating targeted therapies for atherosclerosis before the disease forms.

Coronary artery disease is a narrowing of the small blood vessels that supply blood and oxygen to the heart.

Tapan Chatterjee, PhD, and researchers in the division of cardiovascular diseases at UC found through global gene expression analysis (measurement of the activity of thousands of genes at once) that this outer fat tissue -- known as perivascular fat tissue -- is different from subcutaneous (beneath the skin) fat tissues in other parts of the body.

Research has previously shown that perivascular fat tissue in humans with coronary artery diseases is highly inflamed, leading to the belief that dysfunctional perivascular fat is the real culprit in the formation of coronary artery diseases.

Chatterjee's team was able to replicate this inflammation in animal models.

"The proximity of the perivascular fat to the artery easily influences the function of the coronary blood vessel wall," Chatterjee says. "The perivascular fat is very sensitive to high-fat diet induced inflammatory changes in mice. We found that by transplanting perivascular fat from high-fat diet fed obese mice to the carotid artery of lean mice, the tissue was detrimental to the blood vessel wall and promptly caused disease to form there.

"Our next steps will be to identify various secreted factors, or signals, from perivascular fat tissue of obese mice that could negatively influence the functions of the blood vessel wall," he continues. "We believe this cross-talk between perivascular fat and the coronary artery is very important in triggering coronary artery diseases. We hope this knowledge helps in targeting the molecules before the onset of coronary artery diseases and treating patients before they ever experience the disease."

This study was funded by the National Heart Lung and Blood Institute.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. The original article was written by Katie Pence. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati Academic Health Center. "Fat outside of arteries may influence onset of coronary artery disease." ScienceDaily. ScienceDaily, 20 April 2012. <www.sciencedaily.com/releases/2012/04/120420123901.htm>.
University of Cincinnati Academic Health Center. (2012, April 20). Fat outside of arteries may influence onset of coronary artery disease. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2012/04/120420123901.htm
University of Cincinnati Academic Health Center. "Fat outside of arteries may influence onset of coronary artery disease." ScienceDaily. www.sciencedaily.com/releases/2012/04/120420123901.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins