Featured Research

from universities, journals, and other organizations

Compounds shown to thwart stubborn pathogen's social propensity

Date:
August 21, 2012
Source:
University of Wisconsin-Madison
Summary:
Certain small molecule chemicals that can disrupt quorum sensing in A. baumanni have been identified, providing a glimmer of hope that the stubborn pathogen can be tamed.

Acinetobacter baumanni, a pathogenic bacterium that is a poster child of deadly hospital acquired infections, is one tough customer.

Related Articles


It resists most antibiotics, is seemingly immune to disinfectants, and can survive desiccation with ease. Indeed, the prevalence with which it infects soldiers wounded in Iraq earned it the nickname "Iraqibacter."

In the United States, it is the bane of hospitals, opportunistically infecting patients through open wounds, catheters and breathing tubes. Some estimates suggest it kills tens of thousands of people annually.

But like many species of bacteria, A. baumanni is a social creature. In order to unleash its pathogenic potential, current research suggests that it must accumulate into large colonies or aggregate into "biofilms." To do this, it uses a microbial trick called quorum sensing, where chemical signals are used by the bacterium to gather and sense a critical mass of cells, which then act in unison to exert virulence, which in human patients can manifest itself in the form of pneumonia as well as urinary tract and blood infections.

Interfering with the quorum sensing behavior, some scientists think, may prove to be the Achilles heel of A. baumanni and other microbial pathogens, and new research by chemists at the University of Wisconsin-Madison now gives traction to that idea.

In a study by UW-Madison chemistry Professor Helen Blackwell and her colleagues, and published online in the journal ACS Chemical Biology, certain small molecule chemicals that can disrupt quorum sensing in A. baumanni have been identified, providing a glimmer of hope that the stubborn pathogen can be tamed.

"Right now, there are no approved drugs out there to modulate (quorum sensing), explains Blackwell, a leading expert on the phenomenon in microbes. "The strategy is not to kill the bacterium, but to keep it from behaving badly."

Blackwell explains that A. baumanni and other bacterial pathogens behave differently once a certain population threshold is crossed: "When working as a group, they initiate behaviors different from those observed in an individual cell. They have the ability to take on more complex tasks, and many pathogens use quorum sensing to initiate certain group behaviors."

In A. baumanni and other troublesome microbes, those behaviors include increased virulence and the ability to form biofilms, a state that in A. baumanni is linked it its ability to persist on surfaces, sometimes for weeks at a time, and withstand antibiotic treatment.

Quorum sensing is governed by chemical signaling, notes Blackwell. Bacteria can get a sense of how many cells have gathered by assessing the concentration of chemical signals that they emit. By interfering with those signals, it may be possible to control behaviors such as biofilm formation and movement and thereby limit the virulence of A. baumanni.

"The way a quorum sensing modulator would work is that it wouldn't kill (the microbes), it would just just keep them from behaving badly," says Blackwell.

Combing libraries of potential quorum sensing modulators, Blackwell and her colleagues have identified a handful of compounds that effectively disrupt the signaling pathway A. baumanni depends on.

Although the compounds look promising, Blackwell emphasizes that they will likely find their first use in the lab as research tools. Quorum sensing is still not well understood, she explains, and much more research needs to be done before these compounds or others can be deployed in hospitals and other settings to disrupt deadly pathogens.

However, Blackwell expressed confidence that more such quorum sensing compounds remain to be found and next-generation agents may then be ready to tackle pathogens that are rapidly evolving resistance to our best drugs.

In addition to Blackwell, co-authors of the new research include graduate students Danielle M. Stacy and Michael A. Welsh, also of UW-Madison's Department of Chemistry; and Prof. Philip N. Rather of Emory University. The work was funded by the National Institutes of Health, the Greater Milwaukee Foundation Shaw Scientist Program, the Burroughs Wellcome Fund, and Johnson & Johnson.


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. The original article was written by Terry Devitt. Note: Materials may be edited for content and length.


Journal Reference:

  1. Danielle M. Stacy, Michael A. Welsh, Philip N. Rather, Helen E. Blackwell. Attenuation of Quorum Sensing in the PathogenAcinetobacter baumanniiUsing Non-nativeN-Acyl Homoserine Lactones. ACS Chemical Biology, 2012; 120814105147005 DOI: 10.1021/cb300351x

Cite This Page:

University of Wisconsin-Madison. "Compounds shown to thwart stubborn pathogen's social propensity." ScienceDaily. ScienceDaily, 21 August 2012. <www.sciencedaily.com/releases/2012/08/120821162531.htm>.
University of Wisconsin-Madison. (2012, August 21). Compounds shown to thwart stubborn pathogen's social propensity. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2012/08/120821162531.htm
University of Wisconsin-Madison. "Compounds shown to thwart stubborn pathogen's social propensity." ScienceDaily. www.sciencedaily.com/releases/2012/08/120821162531.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins