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Rapid response in cases of smoke poisoning

Date:
September 4, 2012
Source:
University of Zurich
Summary:
Smoke poisoning can be caused by a number of things, including cyanides, the salts of hydrocyanic acid. Because the quick diagnosis and treatment of victims with cyanide poisoning is critical and often lifesaving, it is very surprising that a cyanide test for emergency situations is not yet available. Now, chemists have developed a simple and reliable procedure to detect blood cyanide in less than two minutes.

Two-step procedure to detect blood cyanide: 1) The chemosensor is added to the blood sample. If cyanide is present in the blood, it forms a purple complex with the chemosensor. The solution is squeezed through a syringe containing a solid phase. 2) The solid phase is rinsed with water to remove the blood, leaving the violet complex that the cyanide formed with the chemosensor.
Credit: UZH

Smoke poisoning can be caused by a number of things, including cyanides, the salts of hydrocyanic acid. Because the quick diagnosis and treatment of victims with cyanide poisoning is critical and often lifesaving, it is very surprising that a cyanide test for emergency situations is not yet available. Now, chemists at the University of Zurich have developed a simple and reliable procedure to detect blood cyanide in less than two minutes.

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The main cause of cyanide poisoning is smoke inhalation in closed spaces during fires. Cyanides, the salts of hydrocyanic acid, inhibit cellular respiration and may lead to coma or death. The rapid administration of a cyanide antidote is essential for successful treatment. Previously, detecting cyanide in the blood took up to an hour and could only be performed in the laboratory, a lengthy process that is poorly suited for emergency situations. As a result, emergency doctors and paramedics are forced to administer antidotes based solely on presumptive diagnoses. Now, chemists at the University of Zurich have succeeded in detecting blood cyanide in less than two minutes and without any laboratory equipment: UZH chemists Christine Männel-Croisé and Felix Zelder combined a cyanide color test with an extraction method to produce results quickly and reliably.

The newly developed procedure works with only a tiny drop of blood mixed in a detection vial with a pH buffer, water, and a cobalt-based chemosensor. If the blood contains cyanide, the solid phase of the vial turns purple.

Faster, easier, more versatile

"What I like most about our method is that detection is possible solely with the naked eye, and it needs only a drop of blood," says Zelder. Quantitative measurements are also possible, thereby enabling emergency responders to determine the grade of cyanide poisoning. The correct dosage of antidote can be chosen, and detoxification can be monitored during treatment. "In principle, our method meets all the requirements for application in emergency situations," explains Christine Männel-Croisé. Currently, Männel-Croisé and Zelder are in discussion with paramedics to test their method in cases of emergency.


Story Source:

The above story is based on materials provided by University of Zurich. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christine Männel-Croisé, Felix Zelder. Rapid visual detection of blood cyanide. Analytical Methods, 2012; 4 (9): 2632 DOI: 10.1039/c2ay25595b

Cite This Page:

University of Zurich. "Rapid response in cases of smoke poisoning." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904100039.htm>.
University of Zurich. (2012, September 4). Rapid response in cases of smoke poisoning. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2012/09/120904100039.htm
University of Zurich. "Rapid response in cases of smoke poisoning." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904100039.htm (accessed January 29, 2015).

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