Featured Research

from universities, journals, and other organizations

Screening method aids RNA drug development research

Date:
October 9, 2012
Source:
Scripps Research Institute
Summary:
Scientists have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds. This novel technology may lead to more efficient drug development.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds. This novel technology may lead to more efficient drug development.

The study was published in the October 9, 2012 issue of the journal Nature Communications.

RNA has multiple biological functions, including encoding and translating proteins from genes and regulating the amount of protein expressed under various cellular conditions. Recent studies have identified RNA as a "molecular switch" that controls cellular events such as gene expression, making RNA an attractive target for small molecules that serve as chemical genetics probes, analytical tools or potential drugs.

However, to date information on which small molecules bind to which parts (structural motifs) of RNA has been sparse, hampering this promising area of research and development. That's where the new study comes in.

"For the first time we have been able to probe what types of small molecules would be good lead drugs to target RNA by probing millions of RNA-ligand combinations," said Matthew Disney, an associate professor at TSRI who authored the study with graduate student Tuan Tran. "In a viral genome, for example, RNA folds such as hairpin loops contribute to disease, but we don't know which hairpin loops should we focus on. In the study, we were able to define those RNA motifs, including hairpin loops, that bind to small molecules and the types of small molecules that bind to RNA."

Disney notes that larger, more chemically diverse small molecule libraries could be screened to provide additional ligands with an affinity for RNA recognition, plus additional RNA motifs preferred by small molecules. The new method could be used to create easily accessible small molecule libraries biased towards binding to RNA.

The new technology will also be used in a computer program designed by Disney that brings together information on the interaction between small molecules and RNA with data on the RNA folds present in segments of the human genome that contribute to specific human diseases.

The study, "Identifying the Preferred RNA Motifs and Chemotypes that Interact by Probing Millions of Combinations," was supported by National Institutes of Health (grant R01 GM079235), the Camille and Henry Dreyfus Foundation and the Research Corporation for Science Advancement.


Story Source:

The above story is based on materials provided by Scripps Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tuan Tran, Matthew D. Disney. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations. Nature Communications, 2012; 3: 1125 DOI: 10.1038/ncomms2119

Cite This Page:

Scripps Research Institute. "Screening method aids RNA drug development research." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009171458.htm>.
Scripps Research Institute. (2012, October 9). Screening method aids RNA drug development research. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/10/121009171458.htm
Scripps Research Institute. "Screening method aids RNA drug development research." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009171458.htm (accessed July 29, 2014).

Share This




More Matter & Energy News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Baluchistan Mining Eyes an Uncertain Future

Baluchistan Mining Eyes an Uncertain Future

AFP (July 29, 2014) Coal mining is one of the major industries in Baluchistan but a lack of infrastructure and frequent accidents mean that the area has yet to hit its potential. Duration: 01:58 Video provided by AFP
Powered by NewsLook.com
Easier Nuclear Construction Promises Fall Short

Easier Nuclear Construction Promises Fall Short

AP (July 29, 2014) The U.S. nuclear industry started building its first new plants using prefabricated Lego-like blocks meant to save time and prevent the cost overruns that crippled the sector decades ago. So far, it's not working. (July 29) Video provided by AP
Powered by NewsLook.com
Lithium Battery 'Holy Grail' Could Provide 4 Times The Power

Lithium Battery 'Holy Grail' Could Provide 4 Times The Power

Newsy (July 28, 2014) Stanford University published its findings for a "pure" lithium ion battery that could have our everyday devices and electric cars running longer. Video provided by Newsy
Powered by NewsLook.com
The Carbon Trap: US Exports Global Warming

The Carbon Trap: US Exports Global Warming

AP (July 28, 2014) AP Investigation: As the Obama administration weans the country off dirty fuels, energy companies are ramping-up overseas coal exports at a heavy price. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins